Optical Coherence Tomography normative peripapillary retinal nerve fiber layer and macular data in children ages 0-5 years.
PURPOSE: To determine reference values for the peripapillary retinal nerve fiber layer (pRNFL) and macula in children ages 0-5 years. DESIGN: Prospective cross-sectional study SETTING: Single large academic pediatric ophthalmology practice STUDY POPULATION: Healthy, full-term children ages 0 to <6 years presenting for surgery under general anesthesia were prospectively recruited for participation. Excluded were children with systemic neurologic disease, optic nerve or retinal disease (even if unilateral), or any bilateral ocular disease process, and eyes with amblyopia, ocular disease, or spherical equivalent refractive error outside of -3.00 to +8.00 diopters. OBSERVATION PROCEDURE: Following general anesthesia, OCT scans of the optic nerve and retina were acquired using an HRA+OCT Spectralis with Flex module (Heidelberg, Germany). Automated segmentation of the pRNFL and retinal layers was followed by manual correction. RESULTS: Data was obtained from normal eyes of fifty-seven participants (mean age = 2.28 ± 1.50 years). Mean global pRNFL thickness was 107.6 ± 10.3 μm. Mean global pRNFL thickness was not dependent on age, but showed a negative relationship with axial length (p=0.01). The mean total macular volume was 8.56 ± 0.259 mm3 (n=38). No relationship was found between the total macular volume and age. The ganglion cell layer (GCL), ganglion cell complex (GCC), and inner nuclear layer (INL) volumes showed an inverse relationship with age while the photoreceptor layers showed a logarithmic increase with age. CONCLUSIONS: Global pRNFL thickness measurements remain stable over time. Macular volume and thickness values of segmented retinal layers reflect the development of the macula with age.
Rotruck, JC; House, RJ; Freedman, SF; Kelly, MP; Enyedi, LB; Prakalapakorn, SG; Lim, ME; El-Dairi, MA
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