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Wide variation in caffeine discontinuation timing in premature infants.

Publication ,  Journal Article
Ji, D; Smith, PB; Clark, RH; Zimmerman, KO; Laughon, M; Ku, L; Greenberg, RG
Published in: J Perinatol
February 2020

OBJECTIVE: To assess site variability and concomitant respiratory support related to the timing of caffeine discontinuation, and compare clinical characteristics of infants who discontinued caffeine before vs. within the last week of hospitalization. STUDY DESIGN: Cohort study of 81,110 infants <35 weeks gestational age and <1500 g birth weight discharged from 304 neonatal intensive care units from 2001-2016. RESULTS: The mean postmenstrual age at caffeine discontinuation ranged from 32 to 37 weeks among sites. Respiratory support at the time of discontinuation was common, but variable, with 0-57% of infants receiving positive airway pressure at caffeine discontinuation by site. Infants who discontinued caffeine within the last week of hospitalization had longer total duration of caffeine, but were discharged from the hospital at an earlier postmenstrual age. CONCLUSION: There was substantial variability among sites in the timing of caffeine discontinuation before discharge and respiratory support at the time of caffeine discontinuation.

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Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

February 2020

Volume

40

Issue

2

Start / End Page

288 / 293

Location

United States

Related Subject Headings

  • Respiration
  • Positive-Pressure Respiration
  • Pediatrics
  • Male
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Hospitalization
 

Citation

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Ji, D., Smith, P. B., Clark, R. H., Zimmerman, K. O., Laughon, M., Ku, L., & Greenberg, R. G. (2020). Wide variation in caffeine discontinuation timing in premature infants. J Perinatol, 40(2), 288–293. https://doi.org/10.1038/s41372-019-0561-0
Ji, Dabin, P Brian Smith, Reese H. Clark, Kanecia O. Zimmerman, Matthew Laughon, Lawrence Ku, and Rachel G. Greenberg. “Wide variation in caffeine discontinuation timing in premature infants.J Perinatol 40, no. 2 (February 2020): 288–93. https://doi.org/10.1038/s41372-019-0561-0.
Ji D, Smith PB, Clark RH, Zimmerman KO, Laughon M, Ku L, et al. Wide variation in caffeine discontinuation timing in premature infants. J Perinatol. 2020 Feb;40(2):288–93.
Ji, Dabin, et al. “Wide variation in caffeine discontinuation timing in premature infants.J Perinatol, vol. 40, no. 2, Feb. 2020, pp. 288–93. Pubmed, doi:10.1038/s41372-019-0561-0.
Ji D, Smith PB, Clark RH, Zimmerman KO, Laughon M, Ku L, Greenberg RG. Wide variation in caffeine discontinuation timing in premature infants. J Perinatol. 2020 Feb;40(2):288–293.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

February 2020

Volume

40

Issue

2

Start / End Page

288 / 293

Location

United States

Related Subject Headings

  • Respiration
  • Positive-Pressure Respiration
  • Pediatrics
  • Male
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Hospitalization