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Advances in Human Lung Transplantation.

Publication ,  Journal Article
Swaminathan, AC; Todd, JL; Palmer, SM
Published in: Annu Rev Med
January 27, 2021

Lung transplantation improves survival and quality of life in patients with advanced pulmonary disease. Over the past several decades, the volume of lung transplants has grown substantially, with increasing transplantation of older and acutely ill individuals facilitated by improved utilization and preservation of available donor organs. Other advances include improvements in the diagnosis and mechanistic understanding of frequent post-transplant complications, such as primary graft dysfunction, acute rejection, and chronic lung allograft dysfunction (CLAD). CLAD occurs as a result of the host immune response to the allograft and is the principal factor limiting long-term survival after lung transplantation. Two distinct clinical phenotypes of CLAD have emerged, bronchiolitis obliterans syndrome and restrictive allograft syndrome, and this distinction has enabled further understanding of underlying immune mechanisms. Building on these advances, ongoing studies are exploring novel approaches to diagnose, prevent, and treat CLAD. Such studies are necessary to improve long-term outcomes for lung transplant recipients.

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Published In

Annu Rev Med

DOI

EISSN

1545-326X

Publication Date

January 27, 2021

Volume

72

Start / End Page

135 / 149

Location

United States

Related Subject Headings

  • Risk Factors
  • Primary Graft Dysfunction
  • Organ Preservation
  • Lung Transplantation
  • Lung Diseases
  • Lung
  • Incidence
  • Humans
  • Global Health
  • General & Internal Medicine
 

Citation

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Swaminathan, A. C., Todd, J. L., & Palmer, S. M. (2021). Advances in Human Lung Transplantation. Annu Rev Med, 72, 135–149. https://doi.org/10.1146/annurev-med-080119-103200
Swaminathan, Aparna C., Jamie L. Todd, and Scott M. Palmer. “Advances in Human Lung Transplantation.Annu Rev Med 72 (January 27, 2021): 135–49. https://doi.org/10.1146/annurev-med-080119-103200.
Swaminathan AC, Todd JL, Palmer SM. Advances in Human Lung Transplantation. Annu Rev Med. 2021 Jan 27;72:135–49.
Swaminathan, Aparna C., et al. “Advances in Human Lung Transplantation.Annu Rev Med, vol. 72, Jan. 2021, pp. 135–49. Pubmed, doi:10.1146/annurev-med-080119-103200.
Swaminathan AC, Todd JL, Palmer SM. Advances in Human Lung Transplantation. Annu Rev Med. 2021 Jan 27;72:135–149.

Published In

Annu Rev Med

DOI

EISSN

1545-326X

Publication Date

January 27, 2021

Volume

72

Start / End Page

135 / 149

Location

United States

Related Subject Headings

  • Risk Factors
  • Primary Graft Dysfunction
  • Organ Preservation
  • Lung Transplantation
  • Lung Diseases
  • Lung
  • Incidence
  • Humans
  • Global Health
  • General & Internal Medicine