Key Pathogenic Factors in Coronavirus Disease 2019-Associated Coagulopathy and Acute Lung Injury Highlighted in a Patient With Copresentation of Acute Myelocytic Leukemia: A Case Report.

Journal Article (Journal Article)

The role of concurrent illness in coronavirus disease 2019 (COVID-19) is unknown. Patients with leukemia may display altered thromboinflammatory responses. We report a 53-year-old man presenting with acute leukemia and COVID-19 who developed thrombotic complications and acute respiratory distress syndrome. Multiple analyses, including rotational thromboelastometry and flow cytometry on blood and bronchoalveolar lavage, are reported to characterize coagulation and immune profiles. The patient developed chemotherapy-induced neutropenia that may have protected his lungs from granulocyte-driven hyperinflammatory acute lung injury. However, neutropenia also alters viral clearing, potentially enabling ongoing viral propagation. This case depicts a precarious equilibrium between leukemia and COVID-19.

Full Text

Duke Authors

Cited Authors

  • Olson, LB; Naqvi, IA; Turner, DJ; Morrison, SA; Kraft, BD; Chen, L; Sullenger, BA; Nair, SK; Que, LG; Levy, JH

Published Date

  • March 30, 2021

Published In

Volume / Issue

  • 15 / 4

Start / End Page

  • e01432 -

PubMed ID

  • 33783367

Pubmed Central ID

  • PMC8330627

Electronic International Standard Serial Number (EISSN)

  • 2575-3126

Digital Object Identifier (DOI)

  • 10.1213/XAA.0000000000001432

Language

  • eng

Conference Location

  • United States