COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study.

Journal Article (Journal Article;Multicenter Study)

Lung transplant recipients (LTR) with coronavirus disease 2019 (COVID-19) may have higher mortality than non-lung solid organ transplant recipients (SOTR), but direct comparisons are limited. Risk factors for mortality specifically in LTR have not been explored. We performed a multicenter cohort study of adult SOTR with COVID-19 to compare mortality by 28 days between hospitalized LTR and non-lung SOTR. Multivariable logistic regression models were used to assess comorbidity-adjusted mortality among LTR vs. non-lung SOTR and to determine risk factors for death in LTR. Of 1,616 SOTR with COVID-19, 1,081 (66%) were hospitalized including 120/159 (75%) LTR and 961/1457 (66%) non-lung SOTR (p = .02). Mortality was higher among LTR compared to non-lung SOTR (24% vs. 16%, respectively, p = .032), and lung transplant was independently associated with death after adjusting for age and comorbidities (aOR 1.7, 95% CI 1.0-2.6, p = .04). Among LTR, chronic lung allograft dysfunction (aOR 3.3, 95% CI 1.0-11.3, p = .05) was the only independent risk factor for mortality and age >65 years, heart failure and obesity were not independently associated with death. Among SOTR hospitalized for COVID-19, LTR had higher mortality than non-lung SOTR. In LTR, chronic allograft dysfunction was independently associated with mortality.

Full Text

Duke Authors

Cited Authors

  • Heldman, MR; Kates, OS; Safa, K; Kotton, CN; Georgia, SJ; Steinbrink, JM; Alexander, BD; Hemmersbach-Miller, M; Blumberg, EA; Crespo, MM; Multani, A; Lewis, AV; Eugene Beaird, O; Haydel, B; La Hoz, RM; Moni, L; Condor, Y; Flores, S; Munoz, CG; Guitierrez, J; Diaz, EI; Diaz, D; Vianna, R; Guerra, G; Loebe, M; Rakita, RM; Malinis, M; Azar, MM; Hemmige, V; McCort, ME; Chaudhry, ZS; Singh, P; Hughes, K; Velioglu, A; Yabu, JM; Morillis, JA; Mehta, SA; Tanna, SD; Ison, MG; Tomic, R; Candace Derenge, A; van Duin, D; Maximin, A; Gilbert, C; Goldman, JD; Sehgal, S; Weisshaar, D; Girgis, RE; Nelson, J; Lease, ED; Limaye, AP; Fisher, CE; UW COVID-19 SOT Study Team,

Published Date

  • August 2021

Published In

Volume / Issue

  • 21 / 8

Start / End Page

  • 2774 - 2784

PubMed ID

  • 34008917

Pubmed Central ID

  • PMC9215359

Electronic International Standard Serial Number (EISSN)

  • 1600-6143

Digital Object Identifier (DOI)

  • 10.1111/ajt.16692


  • eng

Conference Location

  • United States