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COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study.

Publication ,  Journal Article
Heldman, MR; Kates, OS; Safa, K; Kotton, CN; Georgia, SJ; Steinbrink, JM; Alexander, BD; Hemmersbach-Miller, M; Blumberg, EA; Crespo, MM ...
Published in: Am J Transplant
August 2021

Lung transplant recipients (LTR) with coronavirus disease 2019 (COVID-19) may have higher mortality than non-lung solid organ transplant recipients (SOTR), but direct comparisons are limited. Risk factors for mortality specifically in LTR have not been explored. We performed a multicenter cohort study of adult SOTR with COVID-19 to compare mortality by 28 days between hospitalized LTR and non-lung SOTR. Multivariable logistic regression models were used to assess comorbidity-adjusted mortality among LTR vs. non-lung SOTR and to determine risk factors for death in LTR. Of 1,616 SOTR with COVID-19, 1,081 (66%) were hospitalized including 120/159 (75%) LTR and 961/1457 (66%) non-lung SOTR (p = .02). Mortality was higher among LTR compared to non-lung SOTR (24% vs. 16%, respectively, p = .032), and lung transplant was independently associated with death after adjusting for age and comorbidities (aOR 1.7, 95% CI 1.0-2.6, p = .04). Among LTR, chronic lung allograft dysfunction (aOR 3.3, 95% CI 1.0-11.3, p = .05) was the only independent risk factor for mortality and age >65 years, heart failure and obesity were not independently associated with death. Among SOTR hospitalized for COVID-19, LTR had higher mortality than non-lung SOTR. In LTR, chronic allograft dysfunction was independently associated with mortality.

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Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

August 2021

Volume

21

Issue

8

Start / End Page

2774 / 2784

Location

United States

Related Subject Headings

  • Transplant Recipients
  • Surgery
  • SARS-CoV-2
  • Organ Transplantation
  • Lung
  • Humans
  • Cohort Studies
  • COVID-19
  • Aged
  • Adult
 

Citation

APA
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Heldman, M. R., Kates, O. S., Safa, K., Kotton, C. N., Georgia, S. J., Steinbrink, J. M., … UW COVID-19 SOT Study Team. (2021). COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study. Am J Transplant, 21(8), 2774–2784. https://doi.org/10.1111/ajt.16692
Heldman, Madeleine R., Olivia S. Kates, Kassem Safa, Camille N. Kotton, Sarah J. Georgia, Julie M. Steinbrink, Barbara D. Alexander, et al. “COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study.Am J Transplant 21, no. 8 (August 2021): 2774–84. https://doi.org/10.1111/ajt.16692.
Heldman MR, Kates OS, Safa K, Kotton CN, Georgia SJ, Steinbrink JM, et al. COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study. Am J Transplant. 2021 Aug;21(8):2774–84.
Heldman, Madeleine R., et al. “COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study.Am J Transplant, vol. 21, no. 8, Aug. 2021, pp. 2774–84. Pubmed, doi:10.1111/ajt.16692.
Heldman MR, Kates OS, Safa K, Kotton CN, Georgia SJ, Steinbrink JM, Alexander BD, Hemmersbach-Miller M, Blumberg EA, Crespo MM, Multani A, Lewis AV, Eugene Beaird O, Haydel B, La Hoz RM, Moni L, Condor Y, Flores S, Munoz CG, Guitierrez J, Diaz EI, Diaz D, Vianna R, Guerra G, Loebe M, Rakita RM, Malinis M, Azar MM, Hemmige V, McCort ME, Chaudhry ZS, Singh P, Hughes K, Velioglu A, Yabu JM, Morillis JA, Mehta SA, Tanna SD, Ison MG, Tomic R, Candace Derenge A, van Duin D, Maximin A, Gilbert C, Goldman JD, Sehgal S, Weisshaar D, Girgis RE, Nelson J, Lease ED, Limaye AP, Fisher CE, UW COVID-19 SOT Study Team. COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study. Am J Transplant. 2021 Aug;21(8):2774–2784.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

August 2021

Volume

21

Issue

8

Start / End Page

2774 / 2784

Location

United States

Related Subject Headings

  • Transplant Recipients
  • Surgery
  • SARS-CoV-2
  • Organ Transplantation
  • Lung
  • Humans
  • Cohort Studies
  • COVID-19
  • Aged
  • Adult