Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases.
Journal Article (Journal Article)
We present our institution's protocol for evaluating and transplanting thoracic organs from COVID-19 positive donors and report the outcomes to date. Hearts from donors testing positive for COVID-19 on any test were eligible for transplantation at our institution provided the donor exhibited no evidence of hypercoagulability or COVID-19 induced hyperinflammatory state during terminal hospitalization. Lungs were eligible if the donor first tested PCR positive on nasopharyngeal swab (NPS) for COVID-19 > 20 days prior to procurement and had a negative lower respiratory tract specimen. We performed 14 thoracic transplants in 13 recipients using organs from COVID-19 positive donors. None of the recipients or healthcare members acquired COVID-19. No recipients suffered unexpected acute rejection. Patient survival is 92% to date, with graft survival 93%. The use of hearts from COVID-19 positive donors may be safe and effective. Transplantation of lungs is unresolved but may be cautiously pursued under the restricted circumstances.
Full Text
Duke Authors
- DeVore, Adam David
- DiBernardo, Louis Robert
- Glass, Carolyn
- Haney, John Carroll
- Klapper, Jacob A
- Milano, Carmelo Alessio
- Pavlisko, Elizabeth N
- Reynolds, John Michael
- Schroder, Jacob Niall
- Wolfe, Cameron Robert
Cited Authors
- Eichenberger, EM; Coniglio, AC; Milano, C; Schroder, J; Bryner, BS; Spencer, PJ; Haney, JC; Klapper, J; Glass, C; Pavlisko, E; Dibernardo, L; Patel, CB; DeVore, AD; Reynolds, J; Wolfe, CR
Published Date
- October 2022
Published In
Volume / Issue
- 41 / 10
Start / End Page
- 1376 - 1381
PubMed ID
- 35871114
Pubmed Central ID
- PMC9245398
Electronic International Standard Serial Number (EISSN)
- 1557-3117
Digital Object Identifier (DOI)
- 10.1016/j.healun.2022.06.018
Language
- eng
Conference Location
- United States