Role of JAK3 in CD40-mediated signaling.

Journal Article

CD40 is a member of the tumor necrosis factor receptor family and plays an important role in B-cell survival, growth, differentiation, and isotype switching. Recently, CD40 has been shown to associate with JAK3, a member of the family of Janus Kinases, which are nonreceptor protein kinases involved in intracellular signaling mediated by cytokines and growth factors. To investigate the role of JAK3 in CD40-mediated signaling, we studied the effect of CD40 stimulation on B-cell proliferation, IgE isotype switching, and upregulation of surface expression of CD23, ICAM-1, CD80, and LT-alpha in JAK3-deficient patients. Our studies show that stimulation of B cells with monoclonal antibody to CD40 in the presence of interleukin-4 (IL-4) or IL-13 resulted in similar responses in JAK3-deficient patients and normal controls. This suggests that JAK3 is not essential for CD40-mediated B-cell proliferation, isotype switching, and upregulation of CD23, ICAM-1, CD80, and LT-alpha surface expression.

Full Text

Duke Authors

Cited Authors

  • Jabara, HH; Buckley, RH; Roberts, JL; Lefranc, G; Loiselet, J; Khalil, G; Geha, RS

Published Date

  • October 1, 1998

Published In

Volume / Issue

  • 92 / 7

Start / End Page

  • 2435 - 2440

PubMed ID

  • 9746783

International Standard Serial Number (ISSN)

  • 0006-4971

Language

  • eng

Conference Location

  • United States