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Role of JAK3 in CD40-mediated signaling.

Publication ,  Journal Article
Jabara, HH; Buckley, RH; Roberts, JL; Lefranc, G; Loiselet, J; Khalil, G; Geha, RS
Published in: Blood
October 1, 1998

CD40 is a member of the tumor necrosis factor receptor family and plays an important role in B-cell survival, growth, differentiation, and isotype switching. Recently, CD40 has been shown to associate with JAK3, a member of the family of Janus Kinases, which are nonreceptor protein kinases involved in intracellular signaling mediated by cytokines and growth factors. To investigate the role of JAK3 in CD40-mediated signaling, we studied the effect of CD40 stimulation on B-cell proliferation, IgE isotype switching, and upregulation of surface expression of CD23, ICAM-1, CD80, and LT-alpha in JAK3-deficient patients. Our studies show that stimulation of B cells with monoclonal antibody to CD40 in the presence of interleukin-4 (IL-4) or IL-13 resulted in similar responses in JAK3-deficient patients and normal controls. This suggests that JAK3 is not essential for CD40-mediated B-cell proliferation, isotype switching, and upregulation of CD23, ICAM-1, CD80, and LT-alpha surface expression.

Duke Scholars

Published In

Blood

ISSN

0006-4971

Publication Date

October 1, 1998

Volume

92

Issue

7

Start / End Page

2435 / 2440

Location

United States

Related Subject Headings

  • Up-Regulation
  • Signal Transduction
  • Protein-Tyrosine Kinases
  • Polymerase Chain Reaction
  • Membrane Glycoproteins
  • Male
  • Lymphocyte Activation
  • Janus Kinase 3
  • Interleukin-4
  • Interleukin-13
 

Citation

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MLA
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Jabara, H. H., Buckley, R. H., Roberts, J. L., Lefranc, G., Loiselet, J., Khalil, G., & Geha, R. S. (1998). Role of JAK3 in CD40-mediated signaling. Blood, 92(7), 2435–2440.
Jabara, H. H., R. H. Buckley, J. L. Roberts, G. Lefranc, J. Loiselet, G. Khalil, and R. S. Geha. “Role of JAK3 in CD40-mediated signaling.Blood 92, no. 7 (October 1, 1998): 2435–40.
Jabara HH, Buckley RH, Roberts JL, Lefranc G, Loiselet J, Khalil G, et al. Role of JAK3 in CD40-mediated signaling. Blood. 1998 Oct 1;92(7):2435–40.
Jabara, H. H., et al. “Role of JAK3 in CD40-mediated signaling.Blood, vol. 92, no. 7, Oct. 1998, pp. 2435–40.
Jabara HH, Buckley RH, Roberts JL, Lefranc G, Loiselet J, Khalil G, Geha RS. Role of JAK3 in CD40-mediated signaling. Blood. 1998 Oct 1;92(7):2435–2440.

Published In

Blood

ISSN

0006-4971

Publication Date

October 1, 1998

Volume

92

Issue

7

Start / End Page

2435 / 2440

Location

United States

Related Subject Headings

  • Up-Regulation
  • Signal Transduction
  • Protein-Tyrosine Kinases
  • Polymerase Chain Reaction
  • Membrane Glycoproteins
  • Male
  • Lymphocyte Activation
  • Janus Kinase 3
  • Interleukin-4
  • Interleukin-13