Haploidentical bone marrow stem cell transplantation in human severe combined immunodeficiency.

Journal Article (Review)

From May 1992 to March 1993, 50 infants with severe combined immunodeficiency (SCID) were given bone marrow transplants at Duke University Medical Center. None received chemotherapy for conditioning or for graft-versus-host disease (GVHD) prophylaxis. Forty-one received haploidentical parental marrow depleted of T cells by soybean lectin and sheep red blood cell resetting, and nine received HLA-identical marrow. Forty (80%) survived from 1 week to almost 11 years posttransplantation, including nine of nine (100%) HLA-identical marrow recipients and 31 of 41 haploidentical recipients. T-cell function was present within 2 weeks after transplantation of unfractionated HLA-identical marrow, but not until 3 to 4 months after T-cell-depleted haploidentical marrow stem cells. All 37 patients who are more than 4 months posttransplantation have good T-cell function, and all but one have 100% donor T cells. B-cell function developed slowly or not at all in some recipients of haploidentical marrow. Fourteen (four HLA-identical and 10 haploidentical recipients) have some donor B cells; 19 patients are receiving intravenous immune globulin (IVIG) therapy.

Full Text

Duke Authors

Cited Authors

  • Buckley, RH; Schiff, SE; Schiff, RI; Roberts, JL; Markert, ML; Peters, W; Williams, LW; Ward, FE

Published Date

  • October 1993

Published In

Volume / Issue

  • 30 / 4 Suppl 4

Start / End Page

  • 92 - 101

PubMed ID

  • 7905667

International Standard Serial Number (ISSN)

  • 0037-1963

Language

  • eng

Conference Location

  • United States