SNPselector: a web tool for selecting SNPs for genetic association studies.

Journal Article

SUMMARY: Single nucleotide polymorphisms (SNPs) are commonly used for association studies to find genes responsible for complex genetic diseases. With the recent advance of SNP technology, researchers are able to assay thousands of SNPs in a single experiment. But the process of manually choosing thousands of genotyping SNPs for tens or hundreds of genes is time consuming. We have developed a web-based program, SNPselector, to automate the process. SNPselector takes a list of gene names or a list of genomic regions as input and searches the Ensembl genes or genomic regions for available SNPs. It prioritizes these SNPs on their tagging for linkage disequilibrium, SNP allele frequencies and source, function, regulatory potential and repeat status. SNPselector outputs result in compressed Excel spreadsheet files for review by the user. AVAILABILITY: SNPselector is freely available at http://primer.duhs.duke.edu/

Full Text

Duke Authors

Cited Authors

  • Xu, H; Gregory, SG; Hauser, ER; Stenger, JE; Pericak-Vance, MA; Vance, JM; Züchner, S; Hauser, MA

Published Date

  • November 15, 2005

Published In

Volume / Issue

  • 21 / 22

Start / End Page

  • 4181 - 4186

PubMed ID

  • 16179360

International Standard Serial Number (ISSN)

  • 1367-4803

Digital Object Identifier (DOI)

  • 10.1093/bioinformatics/bti682

Language

  • eng

Conference Location

  • England