Malignant melanoma presenting as a mediastinal mass.

Journal Article (Journal Article)

A case of malignant melanoma presenting as a mediastinal mass without an extrathoracic primary is reported. Microscopically the tumor appeared consistent with malignant melanoma, with the presence of focal melanin pigment in large epithelioid cells. Fontana stain confirmed the presence of melanin pigment. Immunohistochemical staining further suggested melanoma, with the tumor cells expressing a HMB45+, S100+ and cytokeratin-phenotype. Electron microscopy showed an abundance of melanosomes confirming the diagnosis of malignant melanoma.

Full Text

Duke Authors

Cited Authors

  • Lau, CL; Bentley, RC; Gockerman, JP; Que, LG; D'Amico, TA

Published Date

  • March 1999

Published In

Volume / Issue

  • 67 / 3

Start / End Page

  • 851 - 852

PubMed ID

  • 10215250

International Standard Serial Number (ISSN)

  • 0003-4975

Digital Object Identifier (DOI)

  • 10.1016/s0003-4975(99)00075-2


  • eng

Conference Location

  • Netherlands