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Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR).

Publication ,  Journal Article
Brummett, BH; Boyle, SH; Siegler, IC; Zuchner, S; Ashley-Koch, A; Williams, RB
Published in: Med Sci Monit
February 2008

BACKGROUND: The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine. A polymorphism in the promoter region (MAOA-uVNTR) affects transcriptional efficiency. Allelic variation in MAOA-uVNTR has been associated with body mass index (BMI). We extended previous work by examining relations among this polymorphism and serum lipid levels. MATERIAL/METHODS: The sample consisted of 74 males enrolled in a study of caregivers for relatives with dementia. Regression models, adjusted for age, race, group status (caregiver/control), and cholesterol lowering medication (yes/no), were used to examine associations between high verses low MAOA-uVNTR activity alleles and total cholesterol, HDL, LDL, VLDL, LDL/HDL ratio, triglycerides, and BMI. RESULTS: Higher total cholesterol (p<0.03), LDL/HDL ratio (p<0.01), triglycerides (p<0.02), and VLDL (p<0.02) were associated with low activity MAOA-uVNTR alleles. HDL and LDL were modestly related to MAOA-uVNTR activity, however, they did not reach the conventional significance level (p<0.07 and p<0.10, respectively). BMI (p<0.74) was unrelated to MAOA-uVNTR transcription. CONCLUSIONS: The present findings suggest that MAOA-uVNTR may influence lipid levels and individuals with less active alleles are at increased health risk.

Duke Scholars

Published In

Med Sci Monit

ISSN

1234-1010

Publication Date

February 2008

Volume

14

Issue

2

Start / End Page

CR57 / CR61

Location

United States

Related Subject Headings

  • Risk Factors
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Monoamine Oxidase
  • Minisatellite Repeats
  • Middle Aged
  • Male
  • Lipids
  • Humans
  • General Clinical Medicine
 

Citation

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MLA
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Brummett, B. H., Boyle, S. H., Siegler, I. C., Zuchner, S., Ashley-Koch, A., & Williams, R. B. (2008). Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR). Med Sci Monit, 14(2), CR57–CR61.
Brummett, Beverly H., Stephen H. Boyle, Ilene C. Siegler, Stephan Zuchner, Allison Ashley-Koch, and Redford B. Williams. “Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR).Med Sci Monit 14, no. 2 (February 2008): CR57–61.
Brummett BH, Boyle SH, Siegler IC, Zuchner S, Ashley-Koch A, Williams RB. Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR). Med Sci Monit. 2008 Feb;14(2):CR57–61.
Brummett, Beverly H., et al. “Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR).Med Sci Monit, vol. 14, no. 2, Feb. 2008, pp. CR57–61.
Brummett BH, Boyle SH, Siegler IC, Zuchner S, Ashley-Koch A, Williams RB. Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR). Med Sci Monit. 2008 Feb;14(2):CR57–CR61.

Published In

Med Sci Monit

ISSN

1234-1010

Publication Date

February 2008

Volume

14

Issue

2

Start / End Page

CR57 / CR61

Location

United States

Related Subject Headings

  • Risk Factors
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Monoamine Oxidase
  • Minisatellite Repeats
  • Middle Aged
  • Male
  • Lipids
  • Humans
  • General Clinical Medicine