Dendritic cell vaccines.

Published

Journal Article (Review)

Dendritic cells are antigen-presenting cells that have been shown to stimulate tumor antigen-specific T cell responses in preclinical studies. Consequently, there has been intense interest in developing dendritic cell based cancer vaccines. A variety of methods for generating dendritic cells, loading them with tumor antigens, and administering them to patients have been described. In recent years, a number of early phase clinical trials have been performed and have demonstrated the safety and feasibility of dendritic cell immunotherapies. A number of these trials have generated valuable preliminary data regarding the clinical and immunologic response to DC-based immunotherapy. The emphasis of dendritic cell immunotherapy research is increasingly shifting toward the development of strategies to increase the potency of dendritic cell vaccine preparations.

Full Text

Duke Authors

Cited Authors

  • Mosca, PJ; Lyerly, HK; Clay, TM; Morse, MA

Published Date

  • January 1, 2007

Published In

Volume / Issue

  • 12 /

Start / End Page

  • 4050 - 4060

PubMed ID

  • 17485358

Pubmed Central ID

  • 17485358

International Standard Serial Number (ISSN)

  • 1093-9946

Digital Object Identifier (DOI)

  • 10.2741/2371

Language

  • eng