Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection.

Journal Article

The hallmark of chronic viral infections is a progressive exhaustion of antigen-specific CD8(+) T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8(+) T cells that makes them dysfunctional. Here, we show that during human chronic HIV-1 infection, a CD8(+) T-cell positive costimulatory pathway mediated by DNAX-activating molecule-1 is also disrupted. Thus, DNAX-activating molecule-1 downregulation on CD8(+) T cells aggravates the impairment of CTL effector function in chronic HIV-1 infection.

Full Text

Duke Authors

Cited Authors

  • Cella, M; Presti, R; Vermi, W; Lavender, K; Turnbull, E; Ochsenbauer-Jambor, C; Kappes, JC; Ferrari, G; Kessels, L; Williams, I; CHAVI Clinical Core B, ; McMichael, AJ; Haynes, BF; Borrow, P; Colonna, M; NIAID Center for HIV/AIDS Vaccine Immunology,

Published Date

  • April 2010

Published In

Volume / Issue

  • 40 / 4

Start / End Page

  • 949 - 954

PubMed ID

  • 20201043

Electronic International Standard Serial Number (EISSN)

  • 1521-4141

Digital Object Identifier (DOI)

  • 10.1002/eji.200940234

Language

  • eng

Conference Location

  • Germany