Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection.
Published
Journal Article
The hallmark of chronic viral infections is a progressive exhaustion of antigen-specific CD8(+) T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8(+) T cells that makes them dysfunctional. Here, we show that during human chronic HIV-1 infection, a CD8(+) T-cell positive costimulatory pathway mediated by DNAX-activating molecule-1 is also disrupted. Thus, DNAX-activating molecule-1 downregulation on CD8(+) T cells aggravates the impairment of CTL effector function in chronic HIV-1 infection.
Full Text
Duke Authors
Cited Authors
- Cella, M; Presti, R; Vermi, W; Lavender, K; Turnbull, E; Ochsenbauer-Jambor, C; Kappes, JC; Ferrari, G; Kessels, L; Williams, I; CHAVI Clinical Core B, ; McMichael, AJ; Haynes, BF; Borrow, P; Colonna, M; NIAID Center for HIV/AIDS Vaccine Immunology,
Published Date
- April 2010
Published In
Volume / Issue
- 40 / 4
Start / End Page
- 949 - 954
PubMed ID
- 20201043
Pubmed Central ID
- 20201043
Electronic International Standard Serial Number (EISSN)
- 1521-4141
Digital Object Identifier (DOI)
- 10.1002/eji.200940234
Language
- eng
Conference Location
- Germany