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Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection.

Publication ,  Journal Article
Cella, M; Presti, R; Vermi, W; Lavender, K; Turnbull, E; Ochsenbauer-Jambor, C; Kappes, JC; Ferrari, G; Kessels, L; Williams, I; McMichael, AJ ...
Published in: Eur J Immunol
April 2010

The hallmark of chronic viral infections is a progressive exhaustion of antigen-specific CD8(+) T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8(+) T cells that makes them dysfunctional. Here, we show that during human chronic HIV-1 infection, a CD8(+) T-cell positive costimulatory pathway mediated by DNAX-activating molecule-1 is also disrupted. Thus, DNAX-activating molecule-1 downregulation on CD8(+) T cells aggravates the impairment of CTL effector function in chronic HIV-1 infection.

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Published In

Eur J Immunol

DOI

EISSN

1521-4141

Publication Date

April 2010

Volume

40

Issue

4

Start / End Page

949 / 954

Location

Germany

Related Subject Headings

  • Virus Replication
  • Viral Proteins
  • Viral Load
  • T-Cell Antigen Receptor Specificity
  • T Lineage-Specific Activation Antigen 1
  • Receptors, Virus
  • Programmed Cell Death 1 Receptor
  • Peptide Fragments
  • Mice
  • Lymphocytic Choriomeningitis
 

Citation

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Cella, M., Presti, R., Vermi, W., Lavender, K., Turnbull, E., Ochsenbauer-Jambor, C., … NIAID Center for HIV/AIDS Vaccine Immunology. (2010). Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection. Eur J Immunol, 40(4), 949–954. https://doi.org/10.1002/eji.200940234
Cella, Marina, Rachel Presti, William Vermi, Kerry Lavender, Emma Turnbull, Christina Ochsenbauer-Jambor, John C. Kappes, et al. “Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection.Eur J Immunol 40, no. 4 (April 2010): 949–54. https://doi.org/10.1002/eji.200940234.
Cella M, Presti R, Vermi W, Lavender K, Turnbull E, Ochsenbauer-Jambor C, et al. Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection. Eur J Immunol. 2010 Apr;40(4):949–54.
Cella, Marina, et al. “Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection.Eur J Immunol, vol. 40, no. 4, Apr. 2010, pp. 949–54. Pubmed, doi:10.1002/eji.200940234.
Cella M, Presti R, Vermi W, Lavender K, Turnbull E, Ochsenbauer-Jambor C, Kappes JC, Ferrari G, Kessels L, Williams I, CHAVI Clinical Core B, McMichael AJ, Haynes BF, Borrow P, Colonna M, NIAID Center for HIV/AIDS Vaccine Immunology. Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection. Eur J Immunol. 2010 Apr;40(4):949–954.
Journal cover image

Published In

Eur J Immunol

DOI

EISSN

1521-4141

Publication Date

April 2010

Volume

40

Issue

4

Start / End Page

949 / 954

Location

Germany

Related Subject Headings

  • Virus Replication
  • Viral Proteins
  • Viral Load
  • T-Cell Antigen Receptor Specificity
  • T Lineage-Specific Activation Antigen 1
  • Receptors, Virus
  • Programmed Cell Death 1 Receptor
  • Peptide Fragments
  • Mice
  • Lymphocytic Choriomeningitis