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Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.

Publication ,  Journal Article
Sheng, SP; Lei, B; James, ML; Lascola, CD; Venkatraman, TN; Jung, JY; Maze, M; Franks, NP; Pearlstein, RD; Sheng, H; Warner, DS
Published in: Anesthesiology
December 2012

BACKGROUND: Xenon has been proven to be neuroprotective in experimental brain injury. The authors hypothesized that xenon would improve outcome from focal cerebral ischemia with a delayed treatment onset and prolonged recovery interval. METHODS: Rats were subjected to 70 min temporary focal ischemia. Ninety minutes later, rats were treated with 0, 15, 30, or 45% Xe for 20 h or 0 or 30% Xe for 8, 20, or 44 h. Outcome was measured after 7 days. In another experiment, after ischemia, rats were maintained at 37.5° or 36.0°C for 20 h with or without 30% Xe. Outcome was assessed 28 days later. Finally, mice were subjected to intracerebral hemorrhage with or without 30% Xe for 20 h. Brain water content, hematoma volume, rotarod function, and microglial activation were measured. RESULTS: Cerebral infarct sizes (mean±SD) for 0, 15, 30, and 45% Xe were 212±27, 176±55, 160±32, and 198±54 mm, respectively (P=0.023). Neurologic scores (median±interquartile range) followed a similar pattern (P=0.002). Infarct size did not vary with treatment duration, but neurologic score improved (P=0.002) at all xenon exposure durations (8, 20, and 44 h). Postischemic treatment with either 30% Xe or subtherapeutic hypothermia (36°C) had no effect on 28-day outcome. Combination of these interventions provided long-term benefit. Xenon improved intracerebral hemorrhage outcome measures. CONCLUSION: Xenon improved focal ischemic outcome at 7, but not 28 days postischemia. Xenon combined with subtherapeutic hypothermia produced sustained recovery benefit. Xenon improved intracerebral hemorrhage outcome. Xenon may have potential for clinical stroke therapy under carefully defined conditions.

Duke Scholars

Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

December 2012

Volume

117

Issue

6

Start / End Page

1262 / 1275

Location

United States

Related Subject Headings

  • Xenon
  • Stroke
  • Rats, Wistar
  • Rats
  • Random Allocation
  • Pilot Projects
  • Neuroprotective Agents
  • Mice, Inbred C57BL
  • Mice
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Sheng, S. P., Lei, B., James, M. L., Lascola, C. D., Venkatraman, T. N., Jung, J. Y., … Warner, D. S. (2012). Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. Anesthesiology, 117(6), 1262–1275. https://doi.org/10.1097/ALN.0b013e3182746b81
Sheng, Siyuan P., Beilei Lei, Michael L. James, Christopher D. Lascola, Talaignair N. Venkatraman, Jin Yong Jung, Mervyn Maze, et al. “Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.Anesthesiology 117, no. 6 (December 2012): 1262–75. https://doi.org/10.1097/ALN.0b013e3182746b81.
Sheng SP, Lei B, James ML, Lascola CD, Venkatraman TN, Jung JY, et al. Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. Anesthesiology. 2012 Dec;117(6):1262–75.
Sheng, Siyuan P., et al. “Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.Anesthesiology, vol. 117, no. 6, Dec. 2012, pp. 1262–75. Pubmed, doi:10.1097/ALN.0b013e3182746b81.
Sheng SP, Lei B, James ML, Lascola CD, Venkatraman TN, Jung JY, Maze M, Franks NP, Pearlstein RD, Sheng H, Warner DS. Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. Anesthesiology. 2012 Dec;117(6):1262–1275.

Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

December 2012

Volume

117

Issue

6

Start / End Page

1262 / 1275

Location

United States

Related Subject Headings

  • Xenon
  • Stroke
  • Rats, Wistar
  • Rats
  • Random Allocation
  • Pilot Projects
  • Neuroprotective Agents
  • Mice, Inbred C57BL
  • Mice
  • Male