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Significance of and risk factors for the development of central airway stenosis after lung transplantation.

Publication ,  Journal Article
Shofer, SL; Wahidi, MM; Davis, WA; Palmer, SM; Hartwig, MG; Lu, Y; Snyder, LD
Published in: Am J Transplant
February 2013

Central airways stenosis (CAS) after lung transplant is a poorly understood complication. Objectives of this study were to determine if CAS was associated with chronic rejection or worse survival after transplant as well as to identify factors associated with CAS in a large cohort of lung transplant recipients. Lung transplant recipients transplanted at a single center were retrospectively reviewed for the development of CAS requiring airway dilation. A total of 467 subjects met inclusion criteria with 60 (13%) of these developing CAS requiring intervention. Of these 60 recipients, 22 (37%) had resolution of CAS with bronchoplasty alone, while 32 (53%) ultimately required stent placement. CAS that required intervention was not a risk factor for the development of bronchiolitis obliterans syndrome or worse overall survival. Significant risk factors for the subsequent development of CAS in a time-dependant multivariable model were pulmonary fungal infections and the need for postoperative tracheostomy. While CAS was not associated with BOS or worse survival, it remains an important complication after lung transplant with potentially preventable risk factors.

Duke Scholars

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

February 2013

Volume

13

Issue

2

Start / End Page

383 / 389

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Homologous
  • Surgery
  • Stents
  • Spirometry
  • Risk Factors
  • Retrospective Studies
  • Prognosis
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shofer, S. L., Wahidi, M. M., Davis, W. A., Palmer, S. M., Hartwig, M. G., Lu, Y., & Snyder, L. D. (2013). Significance of and risk factors for the development of central airway stenosis after lung transplantation. Am J Transplant, 13(2), 383–389. https://doi.org/10.1111/ajt.12017
Shofer, S. L., M. M. Wahidi, W. A. Davis, S. M. Palmer, M. G. Hartwig, Y. Lu, and L. D. Snyder. “Significance of and risk factors for the development of central airway stenosis after lung transplantation.Am J Transplant 13, no. 2 (February 2013): 383–89. https://doi.org/10.1111/ajt.12017.
Shofer SL, Wahidi MM, Davis WA, Palmer SM, Hartwig MG, Lu Y, et al. Significance of and risk factors for the development of central airway stenosis after lung transplantation. Am J Transplant. 2013 Feb;13(2):383–9.
Shofer, S. L., et al. “Significance of and risk factors for the development of central airway stenosis after lung transplantation.Am J Transplant, vol. 13, no. 2, Feb. 2013, pp. 383–89. Pubmed, doi:10.1111/ajt.12017.
Shofer SL, Wahidi MM, Davis WA, Palmer SM, Hartwig MG, Lu Y, Snyder LD. Significance of and risk factors for the development of central airway stenosis after lung transplantation. Am J Transplant. 2013 Feb;13(2):383–389.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

February 2013

Volume

13

Issue

2

Start / End Page

383 / 389

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Homologous
  • Surgery
  • Stents
  • Spirometry
  • Risk Factors
  • Retrospective Studies
  • Prognosis
  • Middle Aged
  • Male