Recent developments in phasing and structure refinement for macromolecular crystallography.

Journal Article (Journal Article;Review)

Central to crystallographic structure solution is obtaining accurate phases in order to build a molecular model, ultimately followed by refinement of that model to optimize its fit to the experimental diffraction data and prior chemical knowledge. Recent advances in phasing and model refinement and validation algorithms make it possible to arrive at better electron density maps and more accurate models.

Full Text

Duke Authors

Cited Authors

  • Adams, PD; Afonine, PV; Grosse-Kunstleve, RW; Read, RJ; Richardson, JS; Richardson, DC; Terwilliger, TC

Published Date

  • October 2009

Published In

Volume / Issue

  • 19 / 5

Start / End Page

  • 566 - 572

PubMed ID

  • 19700309

Pubmed Central ID

  • PMC2763973

Electronic International Standard Serial Number (EISSN)

  • 1879-033X

Digital Object Identifier (DOI)

  • 10.1016/


  • eng

Conference Location

  • England