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Accelerated accumulation of health deficits as a characteristic of aging.

Publication ,  Journal Article
Kulminski, A; Ukraintseva, SV; Akushevich, I; Arbeev, KG; Land, K; Yashin, AI
Published in: Experimental gerontology
October 2007

Cross-sectional analyses show that an index of aging-associated health/well-being deficits, called the "frailty index", can characterize the aging process in humans. This study provides support for such characterization from a longitudinal analysis of the frailty index properties. The data are from the National Long Term Care Survey assessed longitudinally health and functioning of the U.S. elderly in the period 1982-1999. In cross-sectional analysis, the frailty index exhibits accelerated increase with age till oldest-old ages (95+), with possible deceleration thereafter. Longitudinal analysis confirms the accelerated accumulation of deficits in aging individuals. The time-dynamics of the frailty index is affected by two sex-sensitive processes: (i) selection of robust individuals, resulting in a decline of the mean frailty index with age and (ii) accumulation of deficits associated with physiological aging and its interaction with environment, which results in an accelerated increase of individual frailty index prior to death irrespective of chronological age. Current frailty index levels in individuals are more predictive of death than the index past values. Longitudinal analysis provides strong evidence that the cumulative index of health/well-being deficits can characterize aging-associated processes in humans and predict death better than chronological age during short-term periods.

Duke Scholars

Published In

Experimental gerontology

DOI

EISSN

1873-6815

ISSN

0531-5565

Publication Date

October 2007

Volume

42

Issue

10

Start / End Page

963 / 970

Related Subject Headings

  • Sex Characteristics
  • Proportional Hazards Models
  • Male
  • Longitudinal Studies
  • Longevity
  • Humans
  • Health Status Indicators
  • Gerontology
  • Geriatric Assessment
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kulminski, A., Ukraintseva, S. V., Akushevich, I., Arbeev, K. G., Land, K., & Yashin, A. I. (2007). Accelerated accumulation of health deficits as a characteristic of aging. Experimental Gerontology, 42(10), 963–970. https://doi.org/10.1016/j.exger.2007.05.009
Kulminski, Alexander, Svetlana V. Ukraintseva, Igor Akushevich, Konstantin G. Arbeev, Kenneth Land, and Anatoli I. Yashin. “Accelerated accumulation of health deficits as a characteristic of aging.Experimental Gerontology 42, no. 10 (October 2007): 963–70. https://doi.org/10.1016/j.exger.2007.05.009.
Kulminski A, Ukraintseva SV, Akushevich I, Arbeev KG, Land K, Yashin AI. Accelerated accumulation of health deficits as a characteristic of aging. Experimental gerontology. 2007 Oct;42(10):963–70.
Kulminski, Alexander, et al. “Accelerated accumulation of health deficits as a characteristic of aging.Experimental Gerontology, vol. 42, no. 10, Oct. 2007, pp. 963–70. Epmc, doi:10.1016/j.exger.2007.05.009.
Kulminski A, Ukraintseva SV, Akushevich I, Arbeev KG, Land K, Yashin AI. Accelerated accumulation of health deficits as a characteristic of aging. Experimental gerontology. 2007 Oct;42(10):963–970.
Journal cover image

Published In

Experimental gerontology

DOI

EISSN

1873-6815

ISSN

0531-5565

Publication Date

October 2007

Volume

42

Issue

10

Start / End Page

963 / 970

Related Subject Headings

  • Sex Characteristics
  • Proportional Hazards Models
  • Male
  • Longitudinal Studies
  • Longevity
  • Humans
  • Health Status Indicators
  • Gerontology
  • Geriatric Assessment
  • Female