Side population cells in human cancers.

Journal Article (Review)

Cancer stem cells (CSCs) are found in multiple tumor types. While the presence of surface markers selectively expressed on CSCs are used to isolate these cells, no marker or pattern of makers are known to prospectively identify CSCs in many tumor types. In such cases exploitation of stem cell characteristics can be used to identify CSCs and one such characteristic is the capacity to extrude dyes such as Hoechst 33342. Cell that exclude this dye are referred to as side population (SP) cells. These cells share characteristics of CSCs, specifically, they are enriched for tumor initiating capacity, they express stem-like genes, and they are resistant to chemotherapeutic drugs. Dye exclusion is a valuable technique as it identifies a unique population of cells with stem-like characteristics.

Full Text

Duke Authors

Cited Authors

  • Wu, C; Alman, BA

Published Date

  • September 8, 2008

Published In

Volume / Issue

  • 268 / 1

Start / End Page

  • 1 - 9

PubMed ID

  • 18487012

International Standard Serial Number (ISSN)

  • 0304-3835

Digital Object Identifier (DOI)

  • 10.1016/j.canlet.2008.03.048

Language

  • eng

Conference Location

  • Ireland