Skip to main content
Journal cover image

Side population cells in human cancers.

Publication ,  Journal Article
Wu, C; Alman, BA
Published in: Cancer Lett
September 8, 2008

Cancer stem cells (CSCs) are found in multiple tumor types. While the presence of surface markers selectively expressed on CSCs are used to isolate these cells, no marker or pattern of makers are known to prospectively identify CSCs in many tumor types. In such cases exploitation of stem cell characteristics can be used to identify CSCs and one such characteristic is the capacity to extrude dyes such as Hoechst 33342. Cell that exclude this dye are referred to as side population (SP) cells. These cells share characteristics of CSCs, specifically, they are enriched for tumor initiating capacity, they express stem-like genes, and they are resistant to chemotherapeutic drugs. Dye exclusion is a valuable technique as it identifies a unique population of cells with stem-like characteristics.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

September 8, 2008

Volume

268

Issue

1

Start / End Page

1 / 9

Location

Ireland

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplastic Stem Cells
  • Neoplasms
  • Neoplasm Transplantation
  • Neoplasm Proteins
  • Mice, Nude
  • Mice
  • Humans
  • Forecasting
  • Cell Line, Tumor
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wu, C., & Alman, B. A. (2008). Side population cells in human cancers. Cancer Lett, 268(1), 1–9. https://doi.org/10.1016/j.canlet.2008.03.048
Wu, Colleen, and Benjamin A. Alman. “Side population cells in human cancers.Cancer Lett 268, no. 1 (September 8, 2008): 1–9. https://doi.org/10.1016/j.canlet.2008.03.048.
Wu C, Alman BA. Side population cells in human cancers. Cancer Lett. 2008 Sep 8;268(1):1–9.
Wu, Colleen, and Benjamin A. Alman. “Side population cells in human cancers.Cancer Lett, vol. 268, no. 1, Sept. 2008, pp. 1–9. Pubmed, doi:10.1016/j.canlet.2008.03.048.
Wu C, Alman BA. Side population cells in human cancers. Cancer Lett. 2008 Sep 8;268(1):1–9.
Journal cover image

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

September 8, 2008

Volume

268

Issue

1

Start / End Page

1 / 9

Location

Ireland

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplastic Stem Cells
  • Neoplasms
  • Neoplasm Transplantation
  • Neoplasm Proteins
  • Mice, Nude
  • Mice
  • Humans
  • Forecasting
  • Cell Line, Tumor