Overview
The McIntyre Laboratory hopes to improve deep brain stimulation (DBS) for the treatment of movement disorders and provide the fundamental technology necessary for the effective application of DBS to new clinical arenas.
Current Appointments & Affiliations
Professor of Biomedical Engineering
·
2021 - Present
Biomedical Engineering,
Pratt School of Engineering
Professor in Neurosurgery
·
2021 - Present
Neurosurgery,
Neurosurgery
Recent Publications
Localizing beta synchronous neurons in the STN using directional DBS recordings and patient-specific biophysical models.
Journal Article Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · June 2026 ObjectiveLocal field potentials (LFPs) exhibit abnormally elevated beta-band power in the subthalamic nucleus (STN) of patients with Parkinson's disease (PD). To better understand these signals, we coupled advanced biophysical models with experime ... Full text CiteComprehensive map of axonal pathway activation as a function of subthalamic deep brain stimulation location and parameter settings.
Journal Article Brain stimulation · January 2026 BackgroundDeep brain stimulation (DBS) of the subthalamic region is an established therapy for the treatment of Parkinson's disease (PD). Computational models of subthalamic DBS are commonly used in the clinical literature to estimate the brain co ... Full text CiteComparison of structural connectomes for modeling deep brain stimulation pathway activation.
Journal Article NeuroImage · May 2025 IntroductionStructural connectivity models of the brain are commonly employed to identify pathways that are directly activated during deep brain stimulation (DBS). However, various connectomes differ in the technical parameters, parcellation schem ... Full text CiteRecent Grants
Model-Based Analysis of Brain Stimulation and Recording
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2033BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC
ResearchPrincipal Investigator · Awarded by Massachusetts General Hospital · 2024 - 2028Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027View All Grants
Education
Case Western Reserve University ·
2001
Ph.D.