Overview
The McIntyre Laboratory hopes to improve deep brain stimulation (DBS) for the treatment of movement disorders and provide the fundamental technology necessary for the effective application of DBS to new clinical arenas.
Current Appointments & Affiliations
Professor of Biomedical Engineering
·
2021 - Present
Biomedical Engineering,
Pratt School of Engineering
Professor in Neurosurgery
·
2021 - Present
Neurosurgery,
Neurosurgery
Recent Publications
Comparison of structural connectomes for modeling deep brain stimulation pathway activation.
Journal Article NeuroImage · May 2025 IntroductionStructural connectivity models of the brain are commonly employed to identify pathways that are directly activated during deep brain stimulation (DBS). However, various connectomes differ in the technical parameters, parcellation schem ... Full text CiteModel-Based Analysis of Pathway Recruitment During Subthalamic Deep Brain Stimulation.
Journal Article Neuromodulation : journal of the International Neuromodulation Society · April 2024 BackgroundSubthalamic deep brain stimulation (DBS) is an established clinical therapy, but an anatomically clear definition of the underlying neural target(s) of the stimulation remains elusive. Patient-specific models of DBS are commonly used too ... Full text CiteDissecting deep brain stimulation evoked neural activity in the basal ganglia.
Journal Article Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · April 2024 Deep brain stimulation (DBS) is an established therapeutic tool for the treatment of Parkinson's disease (PD). The mechanisms of DBS for PD are likely rooted in modulation of the subthalamo-pallidal network. However, it can be difficult to electrophysiolog ... Full text CiteRecent Grants
BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC
ResearchPrincipal Investigator · Awarded by Massachusetts General Hospital · 2024 - 2028Application of Advanced Imaging and Visualization to Clinical Deep Brain Stimulation
ResearchPrincipal Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2022 - 2028Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027View All Grants
Education, Training & Certifications
Case Western Reserve University ·
2001
Ph.D.