Overview
The McIntyre Laboratory hopes to improve deep brain stimulation (DBS) for the treatment of movement disorders and provide the fundamental technology necessary for the effective application of DBS to new clinical arenas.
Current Duke Appointments & Affiliations
Professor of Biomedical Engineering
·
2021 - Present
Biomedical Engineering,
Pratt School of Engineering
Professor in Neurosurgery
·
2021 - Present
Neurosurgery,
Neurosurgery
Recent Scholarly Works
Theoretical Evaluation of a Parietal Trajectory for Subthalamic Deep Brain Stimulation.
Journal article Stereotact Funct Neurosurg · July 29, 2026 INTRODUCTION: The subthalamic region consists of a complex intersection of many different axonal pathways. Emerging hypotheses in deep brain stimulation (DBS) for Parkinson's disease (PD) suggest that direct stimulation of specific axonal pathways may be l ... Full text Link to item CiteLocalizing beta synchronous neurons in the STN using directional DBS recordings and patient-specific biophysical models.
Journal article Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · June 2026 ObjectiveLocal field potentials (LFPs) exhibit abnormally elevated beta-band power in the subthalamic nucleus (STN) of patients with Parkinson's disease (PD). To better understand these signals, we coupled advanced biophysical models with experime ... Full text CiteComprehensive map of axonal pathway activation as a function of subthalamic deep brain stimulation location and parameter settings.
Journal article Brain stimulation · January 2026 BackgroundDeep brain stimulation (DBS) of the subthalamic region is an established therapy for the treatment of Parkinson's disease (PD). Computational models of subthalamic DBS are commonly used in the clinical literature to estimate the brain co ... Full text CiteRecent Grants
Model-Based Analysis of Brain Stimulation and Recording
ResearchPrincipal Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2025 - 2033BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC
ResearchPrincipal Investigator · Awarded by Massachusetts General Hospital · 2024 - 2028Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027View All Grants
Education
Case Western Reserve University ·
2001
Ph.D.