Overview
The McIntyre Laboratory hopes to improve deep brain stimulation (DBS) for the treatment of movement disorders and provide the fundamental technology necessary for the effective application of DBS to new clinical arenas.
Current Appointments & Affiliations
Professor of Biomedical Engineering
·
2021 - Present
Biomedical Engineering,
Pratt School of Engineering
Professor in Neurosurgery
·
2021 - Present
Neurosurgery,
Neurosurgery
Recent Publications
Comprehensive map of axonal pathway activation as a function of subthalamic deep brain stimulation location and parameter settings.
Journal Article Brain stimulation · November 2025 BackgroundDeep brain stimulation (DBS) of the subthalamic region is an established therapy for the treatment of Parkinson's disease (PD). Computational models of subthalamic DBS are commonly used in the clinical literature to estimate the brain co ... Full text CiteComparison of structural connectomes for modeling deep brain stimulation pathway activation.
Journal Article NeuroImage · May 2025 IntroductionStructural connectivity models of the brain are commonly employed to identify pathways that are directly activated during deep brain stimulation (DBS). However, various connectomes differ in the technical parameters, parcellation schem ... Full text CiteModel-Based Analysis of Pathway Recruitment During Subthalamic Deep Brain Stimulation.
Journal Article Neuromodulation : journal of the International Neuromodulation Society · April 2024 BackgroundSubthalamic deep brain stimulation (DBS) is an established clinical therapy, but an anatomically clear definition of the underlying neural target(s) of the stimulation remains elusive. Patient-specific models of DBS are commonly used too ... Full text CiteRecent Grants
Model-Based Analysis of Brain Stimulation and Recording
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2033BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC
ResearchPrincipal Investigator · Awarded by Massachusetts General Hospital · 2024 - 2028Application of Advanced Imaging and Visualization to Clinical Deep Brain Stimulation
ResearchPrincipal Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2022 - 2028View All Grants
Education, Training & Certifications
Case Western Reserve University ·
2001
Ph.D.