Journal ArticleNeuromodulation : journal of the International Neuromodulation Society · April 2024
BackgroundSubthalamic deep brain stimulation (DBS) is an established clinical therapy, but an anatomically clear definition of the underlying neural target(s) of the stimulation remains elusive. Patient-specific models of DBS are commonly used too ...
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Journal ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · April 2024
Deep brain stimulation (DBS) is an established therapeutic tool for the treatment of Parkinson's disease (PD). The mechanisms of DBS for PD are likely rooted in modulation of the subthalamo-pallidal network. However, it can be difficult to electrophysiolog ...
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Journal ArticleBrain stimulation · November 2023
BackgroundConnectomic modeling studies are expanding understanding of the brain networks that are modulated by deep brain stimulation (DBS) therapies. However, explicit integration of these modeling results into prospective neurosurgical planning ...
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Journal ArticleBrain connectivity · May 2023
Introduction: Models of structural connectivity in the human brain are typically simulated using tractographic approaches. However, the nonlinear fitting of anatomical pathway atlases to de novo subject brains represents a simpler alte ...
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Journal ArticleBrain structure & function · March 2023
The hyperdirect pathway (HDP) represents the main glutamatergic input to the subthalamic nucleus (STN), through which the motor and prefrontal cerebral cortex can modulate basal ganglia activity. Further, direct activation of the motor HDP is thought to be ...
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