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Assessment of retinal nerve fiber layer thickness in healthy, full-term neonates.

Publication ,  Journal Article
Rothman, AL; Sevilla, MB; Freedman, SF; Tong, AY; Tai, V; Tran-Viet, D; Farsiu, S; Toth, CA; El-Dairi, MA
Published in: Am J Ophthalmol
April 2015

PURPOSE: To measure average retinal nerve fiber layer (RNFL) thicknesses in healthy, full-term neonates. DESIGN: Descriptive research to develop normative data. METHODS: Healthy infants born between 37 and 42 weeks postmenstrual age were imaged with hand-held spectral-domain optical coherence tomography. A custom script segmented the RNFL; the fovea and optic nerve center were manually selected. A second script measured the average RNFL thickness along the papillomacular bundle, defined as the arc from -15 degrees to +15 degrees on the axis from the optic nerve to fovea, with radii of 1.1, 1.3, 1.5, and 1.7 mm from the center of the optic disc. Shapiro-Wilk W tests assessed these measurements for normality to determine the age-appropriate radial distance for subsequent analyses. Average RNFL thicknesses for four temporal 45-degree sectors (superior temporal, temporal superior, temporal inferior, and inferior temporal) and the temporal quadrant were calculated and compared to demographic parameters for all infants. RESULTS: Fifty full-term infants were adequately imaged for RNFL analysis. RNFL thicknesses at 1.5 mm radial distance from the optic nerve were the most normally distributed. While there was a trend toward greater mean superior temporal RNFL thickness for both black and Hispanic vs white infants (128 ± 27 μm, 124 ± 30 μm, and 100 ± 19 μm, respectively, P = .04 for both comparisons), there were no other significant differences noted in RNFL thicknesses by race, sex, gestational age, or birth weight. CONCLUSIONS: We present RNFL thickness measurements for healthy, full-term infants that may serve as normative data for future analyses.

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Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

April 2015

Volume

159

Issue

4

Start / End Page

803 / 811

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Term Birth
  • Retinal Ganglion Cells
  • Retina
  • Reference Values
  • Prospective Studies
  • Organ Size
  • Optic Disk
  • Ophthalmology & Optometry
  • Nerve Fibers
 

Citation

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Chicago
ICMJE
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Rothman, A. L., Sevilla, M. B., Freedman, S. F., Tong, A. Y., Tai, V., Tran-Viet, D., … El-Dairi, M. A. (2015). Assessment of retinal nerve fiber layer thickness in healthy, full-term neonates. Am J Ophthalmol, 159(4), 803–811. https://doi.org/10.1016/j.ajo.2015.01.017
Rothman, Adam L., Monica B. Sevilla, Sharon F. Freedman, Amy Y. Tong, Vincent Tai, Du Tran-Viet, Sina Farsiu, Cynthia A. Toth, and Mays A. El-Dairi. “Assessment of retinal nerve fiber layer thickness in healthy, full-term neonates.Am J Ophthalmol 159, no. 4 (April 2015): 803–11. https://doi.org/10.1016/j.ajo.2015.01.017.
Rothman AL, Sevilla MB, Freedman SF, Tong AY, Tai V, Tran-Viet D, et al. Assessment of retinal nerve fiber layer thickness in healthy, full-term neonates. Am J Ophthalmol. 2015 Apr;159(4):803–11.
Rothman, Adam L., et al. “Assessment of retinal nerve fiber layer thickness in healthy, full-term neonates.Am J Ophthalmol, vol. 159, no. 4, Apr. 2015, pp. 803–11. Pubmed, doi:10.1016/j.ajo.2015.01.017.
Rothman AL, Sevilla MB, Freedman SF, Tong AY, Tai V, Tran-Viet D, Farsiu S, Toth CA, El-Dairi MA. Assessment of retinal nerve fiber layer thickness in healthy, full-term neonates. Am J Ophthalmol. 2015 Apr;159(4):803–811.
Journal cover image

Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

April 2015

Volume

159

Issue

4

Start / End Page

803 / 811

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Term Birth
  • Retinal Ganglion Cells
  • Retina
  • Reference Values
  • Prospective Studies
  • Organ Size
  • Optic Disk
  • Ophthalmology & Optometry
  • Nerve Fibers