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Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients.

Publication ,  Journal Article
Ward-Caviness, CK; Kraus, WE; Blach, C; Haynes, CS; Dowdy, E; Miranda, ML; Devlin, RB; Diaz-Sanchez, D; Cascio, WE; Mukerjee, S; Stallings, C ...
Published in: Environ Health Perspect
October 2015

BACKGROUND: The relationship between traffic-related air pollution (TRAP) and risk factors for cardiovascular disease needs to be better understood in order to address the adverse impact of air pollution on human health. OBJECTIVE: We examined associations between roadway proximity and traffic exposure zones, as markers of TRAP exposure, and metabolic biomarkers for cardiovascular disease risk in a cohort of patients undergoing cardiac catheterization. METHODS: We performed a cross-sectional study of 2,124 individuals residing in North Carolina (USA). Roadway proximity was assessed via distance to primary and secondary roadways, and we used residence in traffic exposure zones (TEZs) as a proxy for TRAP. Two categories of metabolic outcomes were studied: measures associated with glucose control, and measures associated with lipid metabolism. Statistical models were adjusted for race, sex, smoking, body mass index, and socioeconomic status (SES). RESULTS: An interquartile-range (990 m) decrease in distance to roadways was associated with higher fasting plasma glucose (β = 2.17 mg/dL; 95% CI: -0.24, 4.59), and the association appeared to be limited to women (β = 5.16 mg/dL; 95% CI: 1.48, 8.84 compared with β = 0.14 mg/dL; 95% CI: -3.04, 3.33 in men). Residence in TEZ 5 (high-speed traffic) and TEZ 6 (stop-and-go traffic), the two traffic zones assumed to have the highest levels of TRAP, was positively associated with high-density lipoprotein cholesterol (HDL-C; β = 8.36; 95% CI: -0.15, 16.9 and β = 5.98; 95% CI: -3.96, 15.9, for TEZ 5 and 6, respectively). CONCLUSION: Proxy measures of TRAP exposure were associated with intermediate metabolic traits associated with cardiovascular disease, including fasting plasma glucose and possibly HDL-C.

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Published In

Environ Health Perspect

DOI

EISSN

1552-9924

Publication Date

October 2015

Volume

123

Issue

10

Start / End Page

1007 / 1014

Location

United States

Related Subject Headings

  • Vehicle Emissions
  • Toxicology
  • Risk Factors
  • Residence Characteristics
  • North Carolina
  • Middle Aged
  • Male
  • Humans
  • Female
  • Fasting
 

Citation

APA
Chicago
ICMJE
MLA
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Ward-Caviness, C. K., Kraus, W. E., Blach, C., Haynes, C. S., Dowdy, E., Miranda, M. L., … Neas, L. M. (2015). Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients. Environ Health Perspect, 123(10), 1007–1014. https://doi.org/10.1289/ehp.1306980
Ward-Caviness, Cavin K., William E. Kraus, Colette Blach, Carol S. Haynes, Elaine Dowdy, Marie Lynn Miranda, Robert B. Devlin, et al. “Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients.Environ Health Perspect 123, no. 10 (October 2015): 1007–14. https://doi.org/10.1289/ehp.1306980.
Ward-Caviness CK, Kraus WE, Blach C, Haynes CS, Dowdy E, Miranda ML, et al. Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients. Environ Health Perspect. 2015 Oct;123(10):1007–14.
Ward-Caviness, Cavin K., et al. “Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients.Environ Health Perspect, vol. 123, no. 10, Oct. 2015, pp. 1007–14. Pubmed, doi:10.1289/ehp.1306980.
Ward-Caviness CK, Kraus WE, Blach C, Haynes CS, Dowdy E, Miranda ML, Devlin RB, Diaz-Sanchez D, Cascio WE, Mukerjee S, Stallings C, Smith LA, Gregory SG, Shah SH, Hauser ER, Neas LM. Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients. Environ Health Perspect. 2015 Oct;123(10):1007–1014.

Published In

Environ Health Perspect

DOI

EISSN

1552-9924

Publication Date

October 2015

Volume

123

Issue

10

Start / End Page

1007 / 1014

Location

United States

Related Subject Headings

  • Vehicle Emissions
  • Toxicology
  • Risk Factors
  • Residence Characteristics
  • North Carolina
  • Middle Aged
  • Male
  • Humans
  • Female
  • Fasting