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Wide field of view swept-source optical coherence tomography for peripheral retinal disease.

Publication ,  Journal Article
McNabb, RP; Grewal, DS; Mehta, R; Schuman, SG; Izatt, JA; Mahmoud, TH; Jaffe, GJ; Mruthyunjaya, P; Kuo, AN
Published in: Br J Ophthalmol
October 2016

BACKGROUND/AIMS: To assess peripheral retinal lesions and the posterior pole in single widefield optical coherence tomography (OCT) volumes. METHODS: A wide field of view (FOV) swept-source OCT (WFOV SSOCT) system was developed using a commercial swept-source laser and a custom sample arm consisting of two indirect ophthalmic lenses. Twenty-seven subjects with peripheral lesions (choroidal melanomas, choroidal naevi, sclerochoroidal calcification, retinitis pigmentosa, diabetic retinopathy, retinoschisis and uveitis) were imaged with the WFOV SSOCT. Volumes were taken in primary gaze. Using the optic nerve to fovea distance as a reference measurement, comparisons were made between the lateral FOV of the WFOV SSOCT, current generation spectral-domain OCT (SDOCT) and widefield scanning laser ophthalmoscopy (SLO) of the same eyes. RESULTS: Peripheral pathologies were captured with WFOV SSOCT in 26 of the 27 subjects. The one not captured was in the far nasal periphery and was not seen in the primary gaze volume. Posterior pole associated pathologies were captured in all subjects. Current generation SDOCT had a mean lateral FOV of 2.08±0.21 optic nerve to fovea distance units, WFOV SSOCT had an FOV of 4.62±0.62 units and SLO had an FOV of 9.35±1.02 units. CONCLUSIONS: WFOV OCT can be used to examine both peripheral retinal pathology and the posterior pole within a single volume acquisition. SLO had the greatest FOV, but does not provide depth information. Future studies using widefield OCT systems will help further delineate the role of WFOV OCT to quantitatively assess and monitor peripheral retinal disease in three dimensions.

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Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

October 2016

Volume

100

Issue

10

Start / End Page

1377 / 1382

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Diseases
  • Retina
  • Reproducibility of Results
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Imaging, Three-Dimensional
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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McNabb, R. P., Grewal, D. S., Mehta, R., Schuman, S. G., Izatt, J. A., Mahmoud, T. H., … Kuo, A. N. (2016). Wide field of view swept-source optical coherence tomography for peripheral retinal disease. Br J Ophthalmol, 100(10), 1377–1382. https://doi.org/10.1136/bjophthalmol-2015-307480
McNabb, Ryan P., Dilraj S. Grewal, Rajvi Mehta, Stefanie G. Schuman, Joseph A. Izatt, Tamer H. Mahmoud, Glenn J. Jaffe, Prithvi Mruthyunjaya, and Anthony N. Kuo. “Wide field of view swept-source optical coherence tomography for peripheral retinal disease.Br J Ophthalmol 100, no. 10 (October 2016): 1377–82. https://doi.org/10.1136/bjophthalmol-2015-307480.
McNabb RP, Grewal DS, Mehta R, Schuman SG, Izatt JA, Mahmoud TH, et al. Wide field of view swept-source optical coherence tomography for peripheral retinal disease. Br J Ophthalmol. 2016 Oct;100(10):1377–82.
McNabb, Ryan P., et al. “Wide field of view swept-source optical coherence tomography for peripheral retinal disease.Br J Ophthalmol, vol. 100, no. 10, Oct. 2016, pp. 1377–82. Pubmed, doi:10.1136/bjophthalmol-2015-307480.
McNabb RP, Grewal DS, Mehta R, Schuman SG, Izatt JA, Mahmoud TH, Jaffe GJ, Mruthyunjaya P, Kuo AN. Wide field of view swept-source optical coherence tomography for peripheral retinal disease. Br J Ophthalmol. 2016 Oct;100(10):1377–1382.

Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

October 2016

Volume

100

Issue

10

Start / End Page

1377 / 1382

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Diseases
  • Retina
  • Reproducibility of Results
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Imaging, Three-Dimensional
  • Humans
  • Female