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Identifying Clinically Significant Prostate Cancers using 3-D In Vivo Acoustic Radiation Force Impulse Imaging with Whole-Mount Histology Validation.

Publication ,  Journal Article
Palmeri, ML; Glass, TJ; Miller, ZA; Rosenzweig, SJ; Buck, A; Polascik, TJ; Gupta, RT; Brown, AF; Madden, J; Nightingale, KR
Published in: Ultrasound Med Biol
June 2016

Overly aggressive prostate cancer (PCa) treatment adversely affects patients and places an unnecessary burden on our health care system. The inability to identify and grade clinically significant PCa lesions is a factor contributing to excessively aggressive PCa treatment, such as radical prostatectomy, instead of more focal, prostate-sparing procedures such as cryotherapy and high-dose radiation therapy. We have performed 3-D in vivo B-mode and acoustic radiation force impulse (ARFI) imaging using a mechanically rotated, side-fire endorectal imaging array to identify regions suspicious for PCa in 29 patients being treated with radical prostatectomies for biopsy-confirmed PCa. Whole-mount histopathology analyses were performed to identify regions of clinically significant/insignificant PCa lesions, atrophy and benign prostatic hyperplasia. Regions of suspicion for PCa were reader-identified in ARFI images based on boundary delineation, contrast, texture and location. These regions of suspicion were compared with histopathology identified lesions using a nearest-neighbor regional localization approach. Of all clinically significant lesions identified on histopathology, 71.4% were also identified using ARFI imaging, including 79.3% of posterior and 33.3% of anterior lesions. Among the ARFI-identified lesions, 79.3% corresponded to clinically significant PCa lesions, with these lesions having higher indices of suspicion than clinically insignificant PCa. ARFI imaging had greater sensitivity for posterior versus anterior lesions because of greater displacement signal-to-noise ratio and finer spatial sampling. Atrophy and benign prostatic hyperplasia can cause appreciable prostate anatomy distortion and heterogeneity that confounds ARFI PCa lesion identification; however, in general, ARFI regions of suspicion did not coincide with these benign pathologies.

Duke Scholars

Published In

Ultrasound Med Biol

DOI

EISSN

1879-291X

Publication Date

June 2016

Volume

42

Issue

6

Start / End Page

1251 / 1262

Location

England

Related Subject Headings

  • Signal-To-Noise Ratio
  • Reproducibility of Results
  • Prostatic Neoplasms
  • Prostate
  • Male
  • Imaging, Three-Dimensional
  • Humans
  • Elasticity Imaging Techniques
  • Acoustics
  • 3202 Clinical sciences
 

Citation

APA
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ICMJE
MLA
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Palmeri, M. L., Glass, T. J., Miller, Z. A., Rosenzweig, S. J., Buck, A., Polascik, T. J., … Nightingale, K. R. (2016). Identifying Clinically Significant Prostate Cancers using 3-D In Vivo Acoustic Radiation Force Impulse Imaging with Whole-Mount Histology Validation. Ultrasound Med Biol, 42(6), 1251–1262. https://doi.org/10.1016/j.ultrasmedbio.2016.01.004
Palmeri, Mark L., Tyler J. Glass, Zachary A. Miller, Stephen J. Rosenzweig, Andrew Buck, Thomas J. Polascik, Rajan T. Gupta, Alison F. Brown, John Madden, and Kathryn R. Nightingale. “Identifying Clinically Significant Prostate Cancers using 3-D In Vivo Acoustic Radiation Force Impulse Imaging with Whole-Mount Histology Validation.Ultrasound Med Biol 42, no. 6 (June 2016): 1251–62. https://doi.org/10.1016/j.ultrasmedbio.2016.01.004.
Palmeri ML, Glass TJ, Miller ZA, Rosenzweig SJ, Buck A, Polascik TJ, et al. Identifying Clinically Significant Prostate Cancers using 3-D In Vivo Acoustic Radiation Force Impulse Imaging with Whole-Mount Histology Validation. Ultrasound Med Biol. 2016 Jun;42(6):1251–62.
Palmeri, Mark L., et al. “Identifying Clinically Significant Prostate Cancers using 3-D In Vivo Acoustic Radiation Force Impulse Imaging with Whole-Mount Histology Validation.Ultrasound Med Biol, vol. 42, no. 6, June 2016, pp. 1251–62. Pubmed, doi:10.1016/j.ultrasmedbio.2016.01.004.
Palmeri ML, Glass TJ, Miller ZA, Rosenzweig SJ, Buck A, Polascik TJ, Gupta RT, Brown AF, Madden J, Nightingale KR. Identifying Clinically Significant Prostate Cancers using 3-D In Vivo Acoustic Radiation Force Impulse Imaging with Whole-Mount Histology Validation. Ultrasound Med Biol. 2016 Jun;42(6):1251–1262.
Journal cover image

Published In

Ultrasound Med Biol

DOI

EISSN

1879-291X

Publication Date

June 2016

Volume

42

Issue

6

Start / End Page

1251 / 1262

Location

England

Related Subject Headings

  • Signal-To-Noise Ratio
  • Reproducibility of Results
  • Prostatic Neoplasms
  • Prostate
  • Male
  • Imaging, Three-Dimensional
  • Humans
  • Elasticity Imaging Techniques
  • Acoustics
  • 3202 Clinical sciences