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Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome.

Publication ,  Journal Article
Hu, F; Vishwanath, K; Salama, JK; Erkanli, A; Peterson, B; Oleson, JR; Lee, WT; Brizel, DM; Ramanujam, N; Dewhirst, MW
Published in: Int J Radiat Oncol Biol Phys
October 1, 2016

PURPOSE: To test whether oxygenation kinetics correlate with the likelihood for local tumor control after fractionated radiation therapy. METHODS AND MATERIALS: We used diffuse reflectance spectroscopy to noninvasively measure tumor vascular oxygenation and total hemoglobin concentration associated with radiation therapy of 5 daily fractions (7.5, 9, or 13.5 Gy/d) in FaDu xenografts. Spectroscopy measurements were obtained immediately before each daily radiation fraction and during the week after radiation therapy. Oxygen saturation and total hemoglobin concentration were computed using an inverse Monte Carlo model. RESULTS: First, oxygenation kinetics during and after radiation therapy, but before tumor volumes changed, were associated with local tumor control. Locally controlled tumors exhibited significantly faster increases in oxygenation after radiation therapy (days 12-15) compared with tumors that recurred locally. Second, within the group of tumors that recurred, faster increases in oxygenation during radiation therapy (day 3-5 interval) were correlated with earlier recurrence times. An area of 0.74 under the receiver operating characteristic curve was achieved when classifying the local control tumors from all irradiated tumors using the oxygen kinetics with a logistic regression model. Third, the rate of increase in oxygenation was radiation dose dependent. Radiation doses ≤9.5 Gy/d did not initiate an increase in oxygenation, whereas 13.5 Gy/d triggered significant increases in oxygenation during and after radiation therapy. CONCLUSIONS: Additional confirmation is required in other tumor models, but these results suggest that monitoring tumor oxygenation kinetics could aid in the prediction of local tumor control after radiation therapy.

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Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

October 1, 2016

Volume

96

Issue

2

Start / End Page

462 / 469

Location

United States

Related Subject Headings

  • Tumor Hypoxia
  • Treatment Outcome
  • Squamous Cell Carcinoma of Head and Neck
  • Radiotherapy, Conformal
  • Radiotherapy Dosage
  • Oxygen
  • Oncology & Carcinogenesis
  • Mice
  • Metabolic Clearance Rate
  • Kinetics
 

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Hu, F., Vishwanath, K., Salama, J. K., Erkanli, A., Peterson, B., Oleson, J. R., … Dewhirst, M. W. (2016). Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome. Int J Radiat Oncol Biol Phys, 96(2), 462–469. https://doi.org/10.1016/j.ijrobp.2016.06.007
Hu, Fangyao, Karthik Vishwanath, Joseph K. Salama, Alaattin Erkanli, Bercedis Peterson, James R. Oleson, Walter T. Lee, David M. Brizel, Nimmi Ramanujam, and Mark W. Dewhirst. “Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome.Int J Radiat Oncol Biol Phys 96, no. 2 (October 1, 2016): 462–69. https://doi.org/10.1016/j.ijrobp.2016.06.007.
Hu F, Vishwanath K, Salama JK, Erkanli A, Peterson B, Oleson JR, et al. Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome. Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2):462–9.
Hu, Fangyao, et al. “Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome.Int J Radiat Oncol Biol Phys, vol. 96, no. 2, Oct. 2016, pp. 462–69. Pubmed, doi:10.1016/j.ijrobp.2016.06.007.
Hu F, Vishwanath K, Salama JK, Erkanli A, Peterson B, Oleson JR, Lee WT, Brizel DM, Ramanujam N, Dewhirst MW. Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome. Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2):462–469.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

October 1, 2016

Volume

96

Issue

2

Start / End Page

462 / 469

Location

United States

Related Subject Headings

  • Tumor Hypoxia
  • Treatment Outcome
  • Squamous Cell Carcinoma of Head and Neck
  • Radiotherapy, Conformal
  • Radiotherapy Dosage
  • Oxygen
  • Oncology & Carcinogenesis
  • Mice
  • Metabolic Clearance Rate
  • Kinetics