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Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients.

Publication ,  Journal Article
Polans, J; Cunefare, D; Cole, E; Keller, B; Mettu, PS; Cousins, SW; Allingham, MJ; Izatt, JA; Farsiu, S
Published in: Opt Lett
January 1, 2017

Optical coherence tomography angiography (OCTA) is a promising technique for non-invasive visualization of vessel networks in the human eye. We debut a system capable of acquiring wide field-of-view (>70°) OCT angiograms without mosaicking. Additionally, we report on enhancing the visualization of peripheral microvasculature using wavefront sensorless adaptive optics (WSAO). We employed a fast WSAO algorithm that enabled wavefront correction in <2  s by iterating the mirror shape at the speed of OCT B-scans rather than volumes. Also, we contrasted ∼7° field-of-view OCTA angiograms acquired in the periphery with and without WSAO correction. On average, WSAO improved the sharpness of microvasculature by 65% in healthy eyes and 38% in diseased eyes. Preliminary observations demonstrated that the location of 7° images could be identified directly from the wide field-of-view angiogram. A pilot study on a normal subject and patients with diabetic retinopathy showed the impact of utilizing WSAO for OCTA when visualizing peripheral vasculature pathologies.

Duke Scholars

Published In

Opt Lett

DOI

EISSN

1539-4794

Publication Date

January 1, 2017

Volume

42

Issue

1

Start / End Page

17 / 20

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Vessels
  • Retina
  • Pilot Projects
  • Optics and Photonics
  • Optics
  • Male
  • Humans
  • Female
  • Diabetic Retinopathy
 

Citation

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Polans, J., Cunefare, D., Cole, E., Keller, B., Mettu, P. S., Cousins, S. W., … Farsiu, S. (2017). Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients. Opt Lett, 42(1), 17–20. https://doi.org/10.1364/OL.42.000017
Polans, James, David Cunefare, Eli Cole, Brenton Keller, Priyatham S. Mettu, Scott W. Cousins, Michael J. Allingham, Joseph A. Izatt, and Sina Farsiu. “Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients.Opt Lett 42, no. 1 (January 1, 2017): 17–20. https://doi.org/10.1364/OL.42.000017.
Polans, James, et al. “Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients.Opt Lett, vol. 42, no. 1, Jan. 2017, pp. 17–20. Pubmed, doi:10.1364/OL.42.000017.
Polans J, Cunefare D, Cole E, Keller B, Mettu PS, Cousins SW, Allingham MJ, Izatt JA, Farsiu S. Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients. Opt Lett. 2017 Jan 1;42(1):17–20.
Journal cover image

Published In

Opt Lett

DOI

EISSN

1539-4794

Publication Date

January 1, 2017

Volume

42

Issue

1

Start / End Page

17 / 20

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Vessels
  • Retina
  • Pilot Projects
  • Optics and Photonics
  • Optics
  • Male
  • Humans
  • Female
  • Diabetic Retinopathy