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Adverse outcomes associated with postoperative atrial arrhythmias after lung transplantation: A meta-analysis and systematic review of the literature.

Publication ,  Journal Article
Waldron, NH; Klinger, RY; Hartwig, MG; Snyder, LD; Daubert, JP; Mathew, JP
Published in: Clin Transplant
April 2017

BACKGROUND: Postoperative atrial arrhythmias (AAs) are common after lung transplantation, but studies are mixed regarding their impact on outcomes. We therefore performed this systematic review and meta-analysis to determine whether AAs after lung transplantation impede postoperative recovery. METHODS: MEDLINE, EMBASE, CINAHL, and the Cochrane Register were searched to identify studies comparing outcomes in adult patients undergoing lung transplantation who experienced postoperative AAs in the immediate postoperative period vs those without postoperative AAs. Our primary outcome was perioperative mortality, and secondary outcomes were length of stay (LOS), postoperative complications, and mid-term (1-6 years) mortality. RESULTS: Nine studies including 2653 patients were included in this analysis. Of this group, 791 (29.8%) had postoperative AAs. Patients with postoperative AAs had significantly higher perioperative (OR 2.70 [95% CI: 1.73-4.19], P<.0001) mortality, longer hospital LOS (MD 8.29 [95% CI: 4.37-12.21] days, P<.0001), more frequent requirement for tracheostomy (OR 4.67 [95% CI: 2.59-8.44], P<.0001), and higher mid-term mortality (OR 1.71 [95% CI: 1.28-2.30], P=.0003). CONCLUSIONS: AAs after lung transplantation are frequent and associated with significantly higher mortality, longer hospital LOS, and requirement for tracheostomy. Given their impact on recovery, prophylactic strategies against AAs need to be developed.

Duke Scholars

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

April 2017

Volume

31

Issue

4

Location

Denmark

Related Subject Headings

  • Surgery
  • Postoperative Complications
  • Lung Transplantation
  • Lung Diseases
  • Humans
  • Arrhythmias, Cardiac
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Waldron, N. H., Klinger, R. Y., Hartwig, M. G., Snyder, L. D., Daubert, J. P., & Mathew, J. P. (2017). Adverse outcomes associated with postoperative atrial arrhythmias after lung transplantation: A meta-analysis and systematic review of the literature. Clin Transplant, 31(4). https://doi.org/10.1111/ctr.12926
Waldron, Nathan H., Rebecca Y. Klinger, Matthew G. Hartwig, Laurie D. Snyder, James P. Daubert, and Joseph P. Mathew. “Adverse outcomes associated with postoperative atrial arrhythmias after lung transplantation: A meta-analysis and systematic review of the literature.Clin Transplant 31, no. 4 (April 2017). https://doi.org/10.1111/ctr.12926.
Waldron NH, Klinger RY, Hartwig MG, Snyder LD, Daubert JP, Mathew JP. Adverse outcomes associated with postoperative atrial arrhythmias after lung transplantation: A meta-analysis and systematic review of the literature. Clin Transplant. 2017 Apr;31(4).
Waldron, Nathan H., et al. “Adverse outcomes associated with postoperative atrial arrhythmias after lung transplantation: A meta-analysis and systematic review of the literature.Clin Transplant, vol. 31, no. 4, Apr. 2017. Pubmed, doi:10.1111/ctr.12926.
Waldron NH, Klinger RY, Hartwig MG, Snyder LD, Daubert JP, Mathew JP. Adverse outcomes associated with postoperative atrial arrhythmias after lung transplantation: A meta-analysis and systematic review of the literature. Clin Transplant. 2017 Apr;31(4).
Journal cover image

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

April 2017

Volume

31

Issue

4

Location

Denmark

Related Subject Headings

  • Surgery
  • Postoperative Complications
  • Lung Transplantation
  • Lung Diseases
  • Humans
  • Arrhythmias, Cardiac
  • 3202 Clinical sciences
  • 1103 Clinical Sciences