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Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins.

Publication ,  Journal Article
Nichols, BS; Llopis, A; Palmer, GM; McCachren, SS; Senlik, O; Miller, D; Brooke, MA; Jokerst, NM; Geradts, J; Greenup, R; Ramanujam, N
Published in: J Biomed Opt
February 1, 2017

We have developed a portable, breast margin assessment probe leveraging diffuse optical spectroscopy to quantify the morphological landscape of breast tumor margins during breast conserving surgery. The approach presented here leverages a custom-made 16-channel annular photodiode imaging array (arranged in a 4 × 4 grid), a raster-scanning imaging platform with precision pressure control, and compressive sensing with an optimized set of eight wavelengths in the visible spectral range. A scalable Monte-Carlo-based inverse model is used to generate optical property [ ? s ? ( ? ) and ? a ( ? ) ] measures for each of the 16 simultaneously captured diffuse reflectance spectra. Subpixel sampling (0.75 mm) is achieved through incremental x , y raster scanning of the imaging probe, providing detailed optical parameter maps of breast margins over a 2 × 2 ?? cm 2 area in ? 9 ?? min . The morphological landscape of a tumor margin is characterized using optical surrogates for the fat to fibroglandular content ratio, which has demonstrated diagnostic utility in delineating tissue subtypes in the breast.

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Published In

J Biomed Opt

DOI

EISSN

1560-2281

Publication Date

February 1, 2017

Volume

22

Issue

2

Start / End Page

26007

Location

United States

Related Subject Headings

  • Spectrum Analysis
  • Optics
  • Monte Carlo Method
  • Miniaturization
  • Mastectomy, Segmental
  • Humans
  • Female
  • Breast Neoplasms
  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
 

Citation

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Nichols, B. S., Llopis, A., Palmer, G. M., McCachren, S. S., Senlik, O., Miller, D., … Ramanujam, N. (2017). Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins. J Biomed Opt, 22(2), 26007. https://doi.org/10.1117/1.JBO.22.2.026007
Nichols, Brandon S., Antonio Llopis, Gregory M. Palmer, Samuel S. McCachren, Ozlem Senlik, David Miller, Martin A. Brooke, et al. “Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins.J Biomed Opt 22, no. 2 (February 1, 2017): 26007. https://doi.org/10.1117/1.JBO.22.2.026007.
Nichols BS, Llopis A, Palmer GM, McCachren SS, Senlik O, Miller D, et al. Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins. J Biomed Opt. 2017 Feb 1;22(2):26007.
Nichols, Brandon S., et al. “Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins.J Biomed Opt, vol. 22, no. 2, Feb. 2017, p. 26007. Pubmed, doi:10.1117/1.JBO.22.2.026007.
Nichols BS, Llopis A, Palmer GM, McCachren SS, Senlik O, Miller D, Brooke MA, Jokerst NM, Geradts J, Greenup R, Ramanujam N. Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins. J Biomed Opt. 2017 Feb 1;22(2):26007.

Published In

J Biomed Opt

DOI

EISSN

1560-2281

Publication Date

February 1, 2017

Volume

22

Issue

2

Start / End Page

26007

Location

United States

Related Subject Headings

  • Spectrum Analysis
  • Optics
  • Monte Carlo Method
  • Miniaturization
  • Mastectomy, Segmental
  • Humans
  • Female
  • Breast Neoplasms
  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering