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TOMMORROW neuropsychological battery: German language validation and normative study.

Publication ,  Journal Article
Romero, HR; Monsch, AU; Hayden, KM; Plassman, BL; Atkins, AS; Keefe, RSE; Brewster, S; Chiang, C; O'Neil, J; Runyan, G; Atkinson, MJ; Budur, K ...
Published in: Alzheimers Dement (N Y)
2018

INTRODUCTION: Assessment of preclinical Alzheimer's disease (AD) requires reliable and validated methods to detect subtle cognitive changes. The battery of standardized cognitive assessments that is used for diagnostic criteria for mild cognitive impairment due to AD in the TOMMORROW study have only been fully validated in English-speaking countries. We conducted a validation and normative study of the German language version of the TOMMORROW neuropsychological test battery, which tests episodic memory, language, visuospatial ability, executive function, and attention. METHODS: German-speaking cognitively healthy controls (NCs) and subjects with AD were recruited from a memory clinic at a Swiss medical center. Construct validity, test-retest, and alternate form reliability were assessed in NCs. Criterion and discriminant validities of the cognitive measures were tested using logistic regression and discriminant analysis. Cross-cultural equivalency of performance of the German language tests was compared with English language tests. RESULTS: A total of 198 NCs and 25 subjects with AD (aged 65-88 years) were analyzed. All German language tests discriminated NCs from persons with AD. Episodic memory tests had the highest potential to discriminate with almost twice the predictive power of any other domain. Test-retest reliability of the test battery was adequate, and alternate form reliability for episodic memory tests was supported. For most tests, age was a significant predictor of group effect sizes; therefore, normative data were stratified by age. Validity and reliability results were similar to those in the published US cognitive testing literature. DISCUSSION: This study establishes the reliability and validity of the German language TOMMORROW test battery, which performed similarly to the English language tests. Some variations in test performance underscore the importance of regional normative values. The German language battery and normative data will improve the precision of measuring cognition and diagnosing incident mild cognitive impairment due to AD in clinical settings in German-speaking countries.

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Published In

Alzheimers Dement (N Y)

DOI

EISSN

2352-8737

Publication Date

2018

Volume

4

Start / End Page

314 / 323

Location

United States

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
 

Citation

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Chicago
ICMJE
MLA
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Romero, H. R., Monsch, A. U., Hayden, K. M., Plassman, B. L., Atkins, A. S., Keefe, R. S. E., … Welsh-Bohmer, K. A. (2018). TOMMORROW neuropsychological battery: German language validation and normative study. Alzheimers Dement (N Y), 4, 314–323. https://doi.org/10.1016/j.trci.2018.06.009
Romero, Heather R., Andreas U. Monsch, Kathleen M. Hayden, Brenda L. Plassman, Alexandra S. Atkins, Richard S. E. Keefe, Shyama Brewster, et al. “TOMMORROW neuropsychological battery: German language validation and normative study.Alzheimers Dement (N Y) 4 (2018): 314–23. https://doi.org/10.1016/j.trci.2018.06.009.
Romero HR, Monsch AU, Hayden KM, Plassman BL, Atkins AS, Keefe RSE, et al. TOMMORROW neuropsychological battery: German language validation and normative study. Alzheimers Dement (N Y). 2018;4:314–23.
Romero, Heather R., et al. “TOMMORROW neuropsychological battery: German language validation and normative study.Alzheimers Dement (N Y), vol. 4, 2018, pp. 314–23. Pubmed, doi:10.1016/j.trci.2018.06.009.
Romero HR, Monsch AU, Hayden KM, Plassman BL, Atkins AS, Keefe RSE, Brewster S, Chiang C, O’Neil J, Runyan G, Atkinson MJ, Crawford S, Budur K, Burns DK, Welsh-Bohmer KA. TOMMORROW neuropsychological battery: German language validation and normative study. Alzheimers Dement (N Y). 2018;4:314–323.
Journal cover image

Published In

Alzheimers Dement (N Y)

DOI

EISSN

2352-8737

Publication Date

2018

Volume

4

Start / End Page

314 / 323

Location

United States

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences