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An Exploratory Radiomics Approach to Quantifying Pulmonary Function in CT Images.

Publication ,  Journal Article
Lafata, KJ; Zhou, Z; Liu, J-G; Hong, J; Kelsey, CR; Yin, F-F
Published in: Sci Rep
August 8, 2019

Contemporary medical imaging is becoming increasingly more quantitative. The emerging field of radiomics is a leading example. By translating unstructured data (i.e., images) into structured data (i.e., imaging features), radiomics can potentially characterize clinically useful imaging phenotypes. In this paper, an exploratory radiomics approach is used to investigate the potential association between quantitative imaging features and pulmonary function in CT images. Thirty-nine radiomic features were extracted from the lungs of 64 patients as potential imaging biomarkers for pulmonary function. Collectively, these features capture the morphology of the lungs, as well as intensity variations, fine-texture, and coarse-texture of the pulmonary tissue. The extracted lung radiomics data was compared to conventional pulmonary function tests. In general, patients with larger lungs of homogeneous, low attenuating pulmonary tissue (as measured via radiomics) were found to be associated with poor spirometry performance and a lower diffusing capacity for carbon monoxide. Unsupervised dynamic data clustering revealed subsets of patients with similar lung radiomic patterns that were found to be associated with similar forced expiratory volume in one second (FEV1) measurements. This implies that patients with similar radiomic feature vectors also presented with comparable spirometry performance, and were separable by varying degrees of pulmonary function as measured by imaging.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

August 8, 2019

Volume

9

Issue

1

Start / End Page

11509

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Respiratory Function Tests
  • Lung Neoplasms
  • Humans
  • Carcinoma, Non-Small-Cell Lung
 

Citation

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Lafata, K. J., Zhou, Z., Liu, J.-G., Hong, J., Kelsey, C. R., & Yin, F.-F. (2019). An Exploratory Radiomics Approach to Quantifying Pulmonary Function in CT Images. Sci Rep, 9(1), 11509. https://doi.org/10.1038/s41598-019-48023-5
Lafata, Kyle J., Zhennan Zhou, Jian-Guo Liu, Julian Hong, Chris R. Kelsey, and Fang-Fang Yin. “An Exploratory Radiomics Approach to Quantifying Pulmonary Function in CT Images.Sci Rep 9, no. 1 (August 8, 2019): 11509. https://doi.org/10.1038/s41598-019-48023-5.
Lafata KJ, Zhou Z, Liu J-G, Hong J, Kelsey CR, Yin F-F. An Exploratory Radiomics Approach to Quantifying Pulmonary Function in CT Images. Sci Rep. 2019 Aug 8;9(1):11509.
Lafata, Kyle J., et al. “An Exploratory Radiomics Approach to Quantifying Pulmonary Function in CT Images.Sci Rep, vol. 9, no. 1, Aug. 2019, p. 11509. Pubmed, doi:10.1038/s41598-019-48023-5.
Lafata KJ, Zhou Z, Liu J-G, Hong J, Kelsey CR, Yin F-F. An Exploratory Radiomics Approach to Quantifying Pulmonary Function in CT Images. Sci Rep. 2019 Aug 8;9(1):11509.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

August 8, 2019

Volume

9

Issue

1

Start / End Page

11509

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Respiratory Function Tests
  • Lung Neoplasms
  • Humans
  • Carcinoma, Non-Small-Cell Lung