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Miniaturized Intracavitary Forward-Looking Ultrasound Transducer for Tissue Ablation.

Publication ,  Journal Article
Kim, H; Wu, H; Cho, N; Zhong, P; Mahmood, K; Lyerly, HK; Jiang, X
Published in: IEEE Trans Biomed Eng
July 2020

OBJECTIVE: This paper aims to develop a miniaturized forward-looking ultrasound transducer for intracavitary tissue ablation, which can be used through an endoscopic device. The internal ultrasound (US) delivery is capable of directly interacting with the target tumor, resolving adverse issues of currently available US devices, such as unintended tissue damage and insufficient delivery of acoustic power. METHODS: To transmit a high acoustic pressure from a small aperture (<3 mm), a double layer transducer (1.3 MHz) was designed and fabricated based on numerical simulations. The electric impedance and the acoustic pressure of the actual device was characterized with an impedance analyzer and a hydrophone. Ex vivo tissue ablation tests and temperature monitoring were then conducted with porcine livers. RESULTS: The acoustic intensity of the transducer was 37.1 W/cm2 under 250 Vpp and 20% duty cycle. The tissue temperature was elevated to 51.8 °C with a 67 Hz pulse-repetition frequency. The temperature profile in the tissue indicated that ultrasound energy was effectively absorbed inside the tissue. During a 5-min sonification, an approximate tissue volume of 2.5 × 2.5 × 1.0 mm3 was ablated, resulting in an irreversible lesion. CONCLUSION: This miniaturized US transducer is a promising medical option for the precise tissue ablation, which can reduce the risk of unintended tissue damage found in noninvasive US treatments. SIGNIFICANCE: Having a small aperture (2 mm), the intracavitary device is capable of ablating a bio tissue in 5 min with a relatively low electric power (<17 W).

Duke Scholars

Published In

IEEE Trans Biomed Eng

DOI

EISSN

1558-2531

Publication Date

July 2020

Volume

67

Issue

7

Start / End Page

2084 / 2093

Location

United States

Related Subject Headings

  • Ultrasonography
  • Ultrasonic Therapy
  • Transducers
  • Temperature
  • Swine
  • High-Intensity Focused Ultrasound Ablation
  • Biomedical Engineering
  • Animals
  • Acoustics
  • 4603 Computer vision and multimedia computation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kim, H., Wu, H., Cho, N., Zhong, P., Mahmood, K., Lyerly, H. K., & Jiang, X. (2020). Miniaturized Intracavitary Forward-Looking Ultrasound Transducer for Tissue Ablation. IEEE Trans Biomed Eng, 67(7), 2084–2093. https://doi.org/10.1109/TBME.2019.2954524
Kim, Howuk, Huaiyu Wu, Namwoo Cho, Pei Zhong, Kamran Mahmood, Herbert Kim Lyerly, and Xiaoning Jiang. “Miniaturized Intracavitary Forward-Looking Ultrasound Transducer for Tissue Ablation.IEEE Trans Biomed Eng 67, no. 7 (July 2020): 2084–93. https://doi.org/10.1109/TBME.2019.2954524.
Kim H, Wu H, Cho N, Zhong P, Mahmood K, Lyerly HK, et al. Miniaturized Intracavitary Forward-Looking Ultrasound Transducer for Tissue Ablation. IEEE Trans Biomed Eng. 2020 Jul;67(7):2084–93.
Kim, Howuk, et al. “Miniaturized Intracavitary Forward-Looking Ultrasound Transducer for Tissue Ablation.IEEE Trans Biomed Eng, vol. 67, no. 7, July 2020, pp. 2084–93. Pubmed, doi:10.1109/TBME.2019.2954524.
Kim H, Wu H, Cho N, Zhong P, Mahmood K, Lyerly HK, Jiang X. Miniaturized Intracavitary Forward-Looking Ultrasound Transducer for Tissue Ablation. IEEE Trans Biomed Eng. 2020 Jul;67(7):2084–2093.

Published In

IEEE Trans Biomed Eng

DOI

EISSN

1558-2531

Publication Date

July 2020

Volume

67

Issue

7

Start / End Page

2084 / 2093

Location

United States

Related Subject Headings

  • Ultrasonography
  • Ultrasonic Therapy
  • Transducers
  • Temperature
  • Swine
  • High-Intensity Focused Ultrasound Ablation
  • Biomedical Engineering
  • Animals
  • Acoustics
  • 4603 Computer vision and multimedia computation