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Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques.

Publication ,  Journal Article
Blasi, M; Wescott, EC; Baker, EJ; Mildenberg, B; LaBranche, C; Rountree, W; Haynes, BF; Saunders, KO; Moody, MA; Negri, D; Santra, S; Cara, A ...
Published in: NPJ Vaccines
May 8, 2020

Despite incredible scientific efforts, there is no cure for HIV infection. While antiretroviral treatment (ART) can help control the virus and prevent transmission, it cannot eradicate HIV from viral reservoirs established before the initiation of therapy. Further, HIV-infected individuals reliably exhibit viral rebound when ART is interrupted, suggesting that the host immune response fails to control viral replication in persistent reservoirs. Therapeutic vaccines are one current approach to improving antiviral host immune responses and enhance long term virus control. In the present study, we used an integrase defective lentiviral vector (IDLV) expressing SIV-Gag to boost anti-Gag specific immune responses in macaques chronically infected with the tier-2 SHIV-1157(QNE)Y173H. A single immunization with IDLV-SIV-Gag induced durable (>20 weeks) virus control in 55% of the vaccinated macaques, correlating with an increased magnitude of SIV-Gag specific CD8+ T-cell responses. IDLV-based therapeutic vaccines are therefore an effective approach to improve virus specific CD8+ T-cell responses and mediate virus control.

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Published In

NPJ Vaccines

DOI

EISSN

2059-0105

Publication Date

May 8, 2020

Volume

5

Issue

1

Start / End Page

36

Location

England
 

Citation

APA
Chicago
ICMJE
MLA
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Blasi, M., Wescott, E. C., Baker, E. J., Mildenberg, B., LaBranche, C., Rountree, W., … Klotman, M. E. (2020). Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques. NPJ Vaccines, 5(1), 36. https://doi.org/10.1038/s41541-020-0186-5
Blasi, Maria, Elizabeth C. Wescott, Erich J. Baker, Benjamin Mildenberg, Celia LaBranche, Wes Rountree, Barton F. Haynes, et al. “Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques.NPJ Vaccines 5, no. 1 (May 8, 2020): 36. https://doi.org/10.1038/s41541-020-0186-5.
Blasi M, Wescott EC, Baker EJ, Mildenberg B, LaBranche C, Rountree W, et al. Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques. NPJ Vaccines. 2020 May 8;5(1):36.
Blasi, Maria, et al. “Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques.NPJ Vaccines, vol. 5, no. 1, May 2020, p. 36. Pubmed, doi:10.1038/s41541-020-0186-5.
Blasi M, Wescott EC, Baker EJ, Mildenberg B, LaBranche C, Rountree W, Haynes BF, Saunders KO, Moody MA, Negri D, Santra S, Cara A, Klotman ME. Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques. NPJ Vaccines. 2020 May 8;5(1):36.

Published In

NPJ Vaccines

DOI

EISSN

2059-0105

Publication Date

May 8, 2020

Volume

5

Issue

1

Start / End Page

36

Location

England