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High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging.

Publication ,  Journal Article
Zhao, Q; Holt, A; Spritzer, CE; DeFrate, LE; McNulty, AL; Wang, N
Published in: Quant Imaging Med Surg
April 3, 2024

BACKGROUND: Diffusion magnetic resonance imaging (MRI) allows for the quantification of water diffusion properties in soft tissues. The goal of this study was to characterize the 3D collagen fiber network in the porcine meniscus using high angular resolution diffusion imaging (HARDI) acquisition with both diffusion tensor imaging (DTI) and generalized q-sampling imaging (GQI). METHODS: Porcine menisci (n=7) were scanned ex vivo using a three-dimensional (3D) HARDI spin-echo pulse sequence with an isotropic resolution of 500 µm at 7.0 Tesla. Both DTI and GQI reconstruction techniques were used to quantify the collagen fiber alignment and visualize the complex collagen network of the meniscus. The MRI findings were validated with conventional histology. RESULTS: DTI and GQI exhibited distinct fiber orientation maps in the meniscus using the same HARDI acquisition. We found that crossing fibers were only resolved with GQI, demonstrating the advantage of GQI over DTI to visualize the complex collagen fiber orientation in the meniscus. Furthermore, the MRI findings were consistent with conventional histology. CONCLUSIONS: HARDI acquisition with GQI reconstruction more accurately resolves the complex 3D collagen architecture of the meniscus compared to DTI reconstruction. In the future, these technologies have the potential to nondestructively assess both normal and abnormal meniscal structure.

Duke Scholars

Published In

Quant Imaging Med Surg

DOI

ISSN

2223-4292

Publication Date

April 3, 2024

Volume

14

Issue

4

Start / End Page

2738 / 2746

Location

China

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 0299 Other Physical Sciences
  • 0205 Optical Physics
  • 0204 Condensed Matter Physics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhao, Q., Holt, A., Spritzer, C. E., DeFrate, L. E., McNulty, A. L., & Wang, N. (2024). High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging. Quant Imaging Med Surg, 14(4), 2738–2746. https://doi.org/10.21037/qims-23-1355
Zhao, Qi, Abigail Holt, Charles E. Spritzer, Louis E. DeFrate, Amy L. McNulty, and Nian Wang. “High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging.Quant Imaging Med Surg 14, no. 4 (April 3, 2024): 2738–46. https://doi.org/10.21037/qims-23-1355.
Zhao Q, Holt A, Spritzer CE, DeFrate LE, McNulty AL, Wang N. High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging. Quant Imaging Med Surg. 2024 Apr 3;14(4):2738–46.
Zhao, Qi, et al. “High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging.Quant Imaging Med Surg, vol. 14, no. 4, Apr. 2024, pp. 2738–46. Pubmed, doi:10.21037/qims-23-1355.
Zhao Q, Holt A, Spritzer CE, DeFrate LE, McNulty AL, Wang N. High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging. Quant Imaging Med Surg. 2024 Apr 3;14(4):2738–2746.

Published In

Quant Imaging Med Surg

DOI

ISSN

2223-4292

Publication Date

April 3, 2024

Volume

14

Issue

4

Start / End Page

2738 / 2746

Location

China

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 0299 Other Physical Sciences
  • 0205 Optical Physics
  • 0204 Condensed Matter Physics