Skip to main content

Genetically engineered polypeptide carrier for thermal targeting of anticancer therapeutics

Publication ,  Journal Article
Meyer, DE; Kong, GA; Dewhirst, MW; Foulon, C; Zalutsky, MR; Chilkoti, A
Published in: American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
March 1, 2000

The thermally-responsive carrier, an elastin-like polypeptide (ELP), is an oligomer of a Val-Pro-Gly-Xaa-Gly pentapeptide repeat. Below a specific, inverse phase transition temperature (Tt), ELPs are highly soluble in aqueous solution. However, upon raising the Tt, they undergo a reversible transition resulting in desolvation and aggregation. Control of the amino acid sequence and the molecular weight of the carrier by genetically encodable synthesis enables precise molecular design of ELPs with an inverse transition of -40 °C. ELP was studied whether it will remain soluble systematically but will accumulate at sites of externally-induced local hyperthermia where the temperature is raised above Tt.

Duke Scholars

Published In

American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

ISSN

0032-3934

Publication Date

March 1, 2000

Volume

41

Issue

1

Start / End Page

1020 / 1021

Related Subject Headings

  • Polymers
  • 3403 Macromolecular and materials chemistry
  • 1007 Nanotechnology
  • 0912 Materials Engineering
  • 0303 Macromolecular and Materials Chemistry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Meyer, D. E., Kong, G. A., Dewhirst, M. W., Foulon, C., Zalutsky, M. R., & Chilkoti, A. (2000). Genetically engineered polypeptide carrier for thermal targeting of anticancer therapeutics. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, 41(1), 1020–1021.
Meyer, D. E., G. A. Kong, M. W. Dewhirst, C. Foulon, M. R. Zalutsky, and A. Chilkoti. “Genetically engineered polypeptide carrier for thermal targeting of anticancer therapeutics.” American Chemical Society, Polymer Preprints, Division of Polymer Chemistry 41, no. 1 (March 1, 2000): 1020–21.
Meyer DE, Kong GA, Dewhirst MW, Foulon C, Zalutsky MR, Chilkoti A. Genetically engineered polypeptide carrier for thermal targeting of anticancer therapeutics. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 2000 Mar 1;41(1):1020–1.
Meyer, D. E., et al. “Genetically engineered polypeptide carrier for thermal targeting of anticancer therapeutics.” American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, vol. 41, no. 1, Mar. 2000, pp. 1020–21.
Meyer DE, Kong GA, Dewhirst MW, Foulon C, Zalutsky MR, Chilkoti A. Genetically engineered polypeptide carrier for thermal targeting of anticancer therapeutics. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 2000 Mar 1;41(1):1020–1021.

Published In

American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

ISSN

0032-3934

Publication Date

March 1, 2000

Volume

41

Issue

1

Start / End Page

1020 / 1021

Related Subject Headings

  • Polymers
  • 3403 Macromolecular and materials chemistry
  • 1007 Nanotechnology
  • 0912 Materials Engineering
  • 0303 Macromolecular and Materials Chemistry