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Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men.

Publication ,  Journal Article
Williams, RB; Surwit, RS; Siegler, IC; Ashley-Koch, AE; Collins, AL; Helms, MJ; Georgiades, A; Boyle, SH; Brummett, BH; Barefoot, JC; Kuhn, CM ...
Published in: Psychosom Med
September 2010

OBJECTIVE: To use measures of cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5HIAA) and genotype of a functional polymorphism of the monoamine oxidase A gene promoter (MAOA-uVNTR) to study the role of central nervous system (CNS) serotonin in clustering of hostility, other psychosocial, metabolic and cardiovascular endophenotypes. METHODS: In 86 healthy male volunteers, we evaluated CSF levels of the primary serotonin metabolite 5HIAA and MAOA-uVNTR genotype for association with a panel of 29 variables assessing hostility, other psychosocial, metabolic, and cardiovascular endophenotypes. RESULTS: The correlations of 5HIAA with these endophenotypes in men with more active MAOA-uVNTR alleles were significantly different from those of men with less active alleles for 15 of the 29 endophenotypes. MAOA-uVNTR genotype and CSF 5HIAA interacted to explain 20% and 22% of the variance, respectively, in scores on one factor wherein high scores reflected a less healthy psychosocial profile and a second factor wherein high score reflected increased insulin resistance, body mass index, blood pressure and hostility. In men with less active alleles, higher 5HIAA was associated with more favorable profiles of hostility, other psychosocial, metabolic and cardiovascular endophenotypes; in men with more active alleles, higher 5HIAA was associated with less favorable profiles. CONCLUSIONS: These findings indicate that, in men, indices of CNS serotonin function influence the expression and clustering of hostility, other psychosocial, metabolic and cardiovascular endophenotypes that have been shown to increase risk of developing cardiovascular disease. The findings are consistent with the hypothesis that increased CNS serotonin is associated with a more favorable psychosocial/metabolic/cardiovascular profile, whereas decreased CNS serotonin function is associated with a less favorable profile.

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Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

September 2010

Volume

72

Issue

7

Start / End Page

601 / 607

Location

United States

Related Subject Headings

  • Serotonin
  • Risk Factors
  • Psychiatry
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Monoamine Oxidase
  • Metabolic Syndrome
  • Male
  • Hydroxyindoleacetic Acid
  • Humans
 

Citation

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Williams, R. B., Surwit, R. S., Siegler, I. C., Ashley-Koch, A. E., Collins, A. L., Helms, M. J., … Kuhn, C. M. (2010). Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men. Psychosom Med, 72(7), 601–607. https://doi.org/10.1097/PSY.0b013e3181eb9d67
Williams, Redford B., Richard S. Surwit, Ilene C. Siegler, Allison E. Ashley-Koch, Ann L. Collins, Michael J. Helms, Anastasia Georgiades, et al. “Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men.Psychosom Med 72, no. 7 (September 2010): 601–7. https://doi.org/10.1097/PSY.0b013e3181eb9d67.
Williams RB, Surwit RS, Siegler IC, Ashley-Koch AE, Collins AL, Helms MJ, et al. Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men. Psychosom Med. 2010 Sep;72(7):601–7.
Williams, Redford B., et al. “Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men.Psychosom Med, vol. 72, no. 7, Sept. 2010, pp. 601–07. Pubmed, doi:10.1097/PSY.0b013e3181eb9d67.
Williams RB, Surwit RS, Siegler IC, Ashley-Koch AE, Collins AL, Helms MJ, Georgiades A, Boyle SH, Brummett BH, Barefoot JC, Grichnik K, Stafford-Smith M, Suarez EC, Kuhn CM. Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men. Psychosom Med. 2010 Sep;72(7):601–607.

Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

September 2010

Volume

72

Issue

7

Start / End Page

601 / 607

Location

United States

Related Subject Headings

  • Serotonin
  • Risk Factors
  • Psychiatry
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Monoamine Oxidase
  • Metabolic Syndrome
  • Male
  • Hydroxyindoleacetic Acid
  • Humans