Skip to main content
Journal cover image

Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans.

Publication ,  Journal Article
Zaas, AK; Chen, M; Varkey, J; Veldman, T; Hero, AO; Lucas, J; Huang, Y; Turner, R; Gilbert, A; Lambkin-Williams, R; Øien, NC; Nicholson, B ...
Published in: Cell Host Microbe
September 17, 2009

Acute respiratory infections (ARIs) are a common reason for seeking medical attention, and the threat of pandemic influenza will likely add to these numbers. Using human viral challenge studies with live rhinovirus, respiratory syncytial virus, and influenza A, we developed peripheral blood gene expression signatures that distinguish individuals with symptomatic ARIs from uninfected individuals with >95% accuracy. We validated this "acute respiratory viral" signature-encompassing genes with a known role in host defense against viral infections-across each viral challenge. We also validated the signature in an independently acquired data set for influenza A and classified infected individuals from healthy controls with 100% accuracy. In the same data set, we could also distinguish viral from bacterial ARIs (93% accuracy). These results demonstrate that ARIs induce changes in human peripheral blood gene expression that can be used to diagnose a viral etiology of respiratory infection and triage symptomatic individuals.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

September 17, 2009

Volume

6

Issue

3

Start / End Page

207 / 217

Location

United States

Related Subject Headings

  • Virus Physiological Phenomena
  • Virus Diseases
  • Respiratory Tract Infections
  • Influenza, Human
  • Influenza A virus
  • Immunology
  • Humans
  • Gene Expression Profiling
  • Cohort Studies
  • Cells, Cultured
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zaas, A. K., Chen, M., Varkey, J., Veldman, T., Hero, A. O., Lucas, J., … Ginsburg, G. S. (2009). Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans. Cell Host Microbe, 6(3), 207–217. https://doi.org/10.1016/j.chom.2009.07.006
Zaas, Aimee K., Minhua Chen, Jay Varkey, Timothy Veldman, Alfred O. Hero, Joseph Lucas, Yongsheng Huang, et al. “Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans.Cell Host Microbe 6, no. 3 (September 17, 2009): 207–17. https://doi.org/10.1016/j.chom.2009.07.006.
Zaas AK, Chen M, Varkey J, Veldman T, Hero AO, Lucas J, et al. Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans. Cell Host Microbe. 2009 Sep 17;6(3):207–17.
Zaas, Aimee K., et al. “Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans.Cell Host Microbe, vol. 6, no. 3, Sept. 2009, pp. 207–17. Pubmed, doi:10.1016/j.chom.2009.07.006.
Zaas AK, Chen M, Varkey J, Veldman T, Hero AO, Lucas J, Huang Y, Turner R, Gilbert A, Lambkin-Williams R, Øien NC, Nicholson B, Kingsmore S, Carin L, Woods CW, Ginsburg GS. Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans. Cell Host Microbe. 2009 Sep 17;6(3):207–217.
Journal cover image

Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

September 17, 2009

Volume

6

Issue

3

Start / End Page

207 / 217

Location

United States

Related Subject Headings

  • Virus Physiological Phenomena
  • Virus Diseases
  • Respiratory Tract Infections
  • Influenza, Human
  • Influenza A virus
  • Immunology
  • Humans
  • Gene Expression Profiling
  • Cohort Studies
  • Cells, Cultured