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Antibody polyspecificity and neutralization of HIV-1: a hypothesis.

Publication ,  Journal Article
Haynes, BF; Moody, MA; Verkoczy, L; Kelsoe, G; Alam, SM
Published in: Hum Antibodies
2005

HIV-1 has evolved many ways to evade protective host immune responses, thus creating a number of problems for HIV vaccine developers. In particular, durable, broadly specific neutralizing antibodies to HIV-1 have proved difficult to induce with current HIV-1 vaccine candidates. The recent observation that some broadly neutralizing anti-HIV-1 envelope monoclonal antibodies have polyspecific reactivities to host antigens have raised the hypothesis that one reason antibodies against some of the conserved HIV-1 envelope trimer neutralizing epitopes are not routinely made may be down-regulation of some specificities of anti-HIV-1 antibody producing B cells by host B cell tolerance mechanisms.

Duke Scholars

Published In

Hum Antibodies

ISSN

1093-2607

Publication Date

2005

Volume

14

Issue

3-4

Start / End Page

59 / 67

Location

Netherlands

Related Subject Headings

  • Neutralization Tests
  • Immunology
  • Humans
  • HIV-1
  • HIV Antigens
  • HIV Antibodies
  • B-Lymphocytes
  • Antibody Specificity
  • Antibodies, Monoclonal
  • AIDS Vaccines
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Haynes, B. F., Moody, M. A., Verkoczy, L., Kelsoe, G., & Alam, S. M. (2005). Antibody polyspecificity and neutralization of HIV-1: a hypothesis. Hum Antibodies, 14(3–4), 59–67.
Haynes, Barton F., M Anthony Moody, Laurent Verkoczy, Garnett Kelsoe, and S Munir Alam. “Antibody polyspecificity and neutralization of HIV-1: a hypothesis.Hum Antibodies 14, no. 3–4 (2005): 59–67.
Haynes BF, Moody MA, Verkoczy L, Kelsoe G, Alam SM. Antibody polyspecificity and neutralization of HIV-1: a hypothesis. Hum Antibodies. 2005;14(3–4):59–67.
Haynes, Barton F., et al. “Antibody polyspecificity and neutralization of HIV-1: a hypothesis.Hum Antibodies, vol. 14, no. 3–4, 2005, pp. 59–67.
Haynes BF, Moody MA, Verkoczy L, Kelsoe G, Alam SM. Antibody polyspecificity and neutralization of HIV-1: a hypothesis. Hum Antibodies. 2005;14(3–4):59–67.

Published In

Hum Antibodies

ISSN

1093-2607

Publication Date

2005

Volume

14

Issue

3-4

Start / End Page

59 / 67

Location

Netherlands

Related Subject Headings

  • Neutralization Tests
  • Immunology
  • Humans
  • HIV-1
  • HIV Antigens
  • HIV Antibodies
  • B-Lymphocytes
  • Antibody Specificity
  • Antibodies, Monoclonal
  • AIDS Vaccines