Antibody polyspecificity and neutralization of HIV-1: a hypothesis.
Publication
, Journal Article
Haynes, BF; Moody, MA; Verkoczy, L; Kelsoe, G; Alam, SM
Published in: Hum Antibodies
2005
HIV-1 has evolved many ways to evade protective host immune responses, thus creating a number of problems for HIV vaccine developers. In particular, durable, broadly specific neutralizing antibodies to HIV-1 have proved difficult to induce with current HIV-1 vaccine candidates. The recent observation that some broadly neutralizing anti-HIV-1 envelope monoclonal antibodies have polyspecific reactivities to host antigens have raised the hypothesis that one reason antibodies against some of the conserved HIV-1 envelope trimer neutralizing epitopes are not routinely made may be down-regulation of some specificities of anti-HIV-1 antibody producing B cells by host B cell tolerance mechanisms.
Duke Scholars
Published In
Hum Antibodies
ISSN
1093-2607
Publication Date
2005
Volume
14
Issue
3-4
Start / End Page
59 / 67
Location
Netherlands
Related Subject Headings
- Neutralization Tests
- Immunology
- Humans
- HIV-1
- HIV Antigens
- HIV Antibodies
- B-Lymphocytes
- Antibody Specificity
- Antibodies, Monoclonal
- AIDS Vaccines
Citation
APA
Chicago
ICMJE
MLA
NLM
Haynes, B. F., Moody, M. A., Verkoczy, L., Kelsoe, G., & Alam, S. M. (2005). Antibody polyspecificity and neutralization of HIV-1: a hypothesis. Hum Antibodies, 14(3–4), 59–67.
Haynes, Barton F., M Anthony Moody, Laurent Verkoczy, Garnett Kelsoe, and S Munir Alam. “Antibody polyspecificity and neutralization of HIV-1: a hypothesis.” Hum Antibodies 14, no. 3–4 (2005): 59–67.
Haynes BF, Moody MA, Verkoczy L, Kelsoe G, Alam SM. Antibody polyspecificity and neutralization of HIV-1: a hypothesis. Hum Antibodies. 2005;14(3–4):59–67.
Haynes, Barton F., et al. “Antibody polyspecificity and neutralization of HIV-1: a hypothesis.” Hum Antibodies, vol. 14, no. 3–4, 2005, pp. 59–67.
Haynes BF, Moody MA, Verkoczy L, Kelsoe G, Alam SM. Antibody polyspecificity and neutralization of HIV-1: a hypothesis. Hum Antibodies. 2005;14(3–4):59–67.
Published In
Hum Antibodies
ISSN
1093-2607
Publication Date
2005
Volume
14
Issue
3-4
Start / End Page
59 / 67
Location
Netherlands
Related Subject Headings
- Neutralization Tests
- Immunology
- Humans
- HIV-1
- HIV Antigens
- HIV Antibodies
- B-Lymphocytes
- Antibody Specificity
- Antibodies, Monoclonal
- AIDS Vaccines