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Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity.

Publication ,  Journal Article
Shan, S; Flowers, C; Peltz, CD; Sweet, H; Maurer, N; Kwon, E-JG; Krol, A; Yuan, F; Dewhirst, MW
Published in: Cancer Chemother Pharmacol
August 2006

To quantitatively evaluate the extravasation, accumulation and selectivity to tumor tissues of liposomal vincristine (LV), dorsal skin-fold window chambers on athymic mice with or without LX-1, a human small cell lung cancer, xenograft implants and fluorescent intravital microscopy imaging were used. In vitro studies show that minimal loss of fluorescence marker DiI from liposomes occurs after 4 days of inoculation in murine plasma, and the release profiles of DiI-LV and LV were essentially the same with approximately 40% of the encapsulated vincristine sulfate (VCR) released after 26 h. Significantly faster extravasation of DiI-LV from tumor vessels was shown compared to non-tumor tissue after single dose i.v. administration. The relative interstitial amounts at 60 min (RIA(60)) for tumor and non-tumor tissues were 0.837+/-0.314 and 0.012+/-0.091, respectively (P=0.01). DiI-LV accumulation was significantly higher in tumor than in normal tissue, which continued beyond 48 h. Both DiI-LV and LV showed significant antitumor effects in window chambers and in flank tumors, compared with controls and VLS alone. The preferential extravasation of DiI-LV from tumor vasculature as well as its differential retention in tumor tissue provides the basis for the enhancement in antitumor activity of LV over VCR.

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Published In

Cancer Chemother Pharmacol

DOI

ISSN

0344-5704

Publication Date

August 2006

Volume

58

Issue

2

Start / End Page

245 / 255

Location

Germany

Related Subject Headings

  • Vincristine
  • Tissue Distribution
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Neoplasm Transplantation
  • Microscopy, Fluorescence
  • Mice, Nude
  • Mice
  • Liposomes
  • Humans
 

Citation

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Shan, S., Flowers, C., Peltz, C. D., Sweet, H., Maurer, N., Kwon, E.-J., … Dewhirst, M. W. (2006). Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity. Cancer Chemother Pharmacol, 58(2), 245–255. https://doi.org/10.1007/s00280-005-0145-x
Shan, Siqing, Clay Flowers, Cathy D. Peltz, Heather Sweet, Norbert Maurer, Eun-Joo Gina Kwon, Ave Krol, Fan Yuan, and Mark W. Dewhirst. “Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity.Cancer Chemother Pharmacol 58, no. 2 (August 2006): 245–55. https://doi.org/10.1007/s00280-005-0145-x.
Shan S, Flowers C, Peltz CD, Sweet H, Maurer N, Kwon E-JG, et al. Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity. Cancer Chemother Pharmacol. 2006 Aug;58(2):245–55.
Shan, Siqing, et al. “Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity.Cancer Chemother Pharmacol, vol. 58, no. 2, Aug. 2006, pp. 245–55. Pubmed, doi:10.1007/s00280-005-0145-x.
Shan S, Flowers C, Peltz CD, Sweet H, Maurer N, Kwon E-JG, Krol A, Yuan F, Dewhirst MW. Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity. Cancer Chemother Pharmacol. 2006 Aug;58(2):245–255.
Journal cover image

Published In

Cancer Chemother Pharmacol

DOI

ISSN

0344-5704

Publication Date

August 2006

Volume

58

Issue

2

Start / End Page

245 / 255

Location

Germany

Related Subject Headings

  • Vincristine
  • Tissue Distribution
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Neoplasm Transplantation
  • Microscopy, Fluorescence
  • Mice, Nude
  • Mice
  • Liposomes
  • Humans