Skip to main content
Journal cover image

Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies.

Publication ,  Journal Article
Verkoczy, L; Kelsoe, G; Moody, MA; Haynes, BF
Published in: Curr Opin Immunol
June 2011

Although antibodies can be elicited by HIV-1 infection or immunization, those that are broadly neutralizing (bnAbs) are undetectable in most individuals, and when they do arise in HIV-1 infection, only do so years after transmission. Until recently, the reasons for difficulty in inducing such bnAbs have been obscure. Recent technological advances in isolating bnAbs from rare patients have increased our knowledge of their specificities and features, and along with gene-targeting studies, have also begun uncovering evidence of immunoregulatory roadblocks preventing their induction. One crucial avenue towards developing an effective HIV-1 vaccine is to harness this emerging information into the rational design of immunogens and formulation of adjuvants, such that structural and immunological hurdles to routinely eliciting bnAbs can be overcome.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Curr Opin Immunol

DOI

EISSN

1879-0372

Publication Date

June 2011

Volume

23

Issue

3

Start / End Page

383 / 390

Location

England

Related Subject Headings

  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Antibody Specificity
  • Antibodies, Neutralizing
  • AIDS Vaccines
  • 3204 Immunology
  • 1107 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Verkoczy, L., Kelsoe, G., Moody, M. A., & Haynes, B. F. (2011). Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies. Curr Opin Immunol, 23(3), 383–390. https://doi.org/10.1016/j.coi.2011.04.003
Verkoczy, Laurent, Garnett Kelsoe, M Anthony Moody, and Barton F. Haynes. “Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies.Curr Opin Immunol 23, no. 3 (June 2011): 383–90. https://doi.org/10.1016/j.coi.2011.04.003.
Verkoczy L, Kelsoe G, Moody MA, Haynes BF. Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies. Curr Opin Immunol. 2011 Jun;23(3):383–90.
Verkoczy, Laurent, et al. “Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies.Curr Opin Immunol, vol. 23, no. 3, June 2011, pp. 383–90. Pubmed, doi:10.1016/j.coi.2011.04.003.
Verkoczy L, Kelsoe G, Moody MA, Haynes BF. Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies. Curr Opin Immunol. 2011 Jun;23(3):383–390.
Journal cover image

Published In

Curr Opin Immunol

DOI

EISSN

1879-0372

Publication Date

June 2011

Volume

23

Issue

3

Start / End Page

383 / 390

Location

England

Related Subject Headings

  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Antibody Specificity
  • Antibodies, Neutralizing
  • AIDS Vaccines
  • 3204 Immunology
  • 1107 Immunology