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Proton spectroscopy of human brain: effects of age and sex.

Publication ,  Journal Article
Charles, HC; Lazeyras, F; Krishnan, KR; Boyko, OB; Patterson, LJ; Doraiswamy, PM; McDonald, WM
Published in: Prog Neuropsychopharmacol Biol Psychiatry
October 1994
Published version (DOI) Link to item

1. The present study was done to assess the brain metabolites measured by proton magnetic resonance spectroscopy (MRS) in normal individuals. 2. Proton spectroscopy STEAM voxel technique with chemical shift imaging was used to provide localized metabolic information from the brains of 34 normal volunteers (15 males) between the ages of 21 and 75 years. 3. Choline, Creatine and N-acetyl aspartate (NAA) was lower in white matter than gray matter. Choline/NAA and choline/creatine ratios were also lower in white matter. The choline, creatine and NAA were lower in older subjects in the voxel representing cortical and subcortical gray matter. There were no differences between males and females. 4. This preliminary study suggests that age matching is essential for comparative studies of disease states using proton MRS.

Duke Scholars

Hal Cecil Charles
Author Hal Cecil Charles Radiology
K. Ranga Rama Krishnan
Author K. Ranga Rama Krishnan Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...
P. Murali Doraiswamy
Author P. Murali Doraiswamy Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...

Published In

Prog Neuropsychopharmacol Biol Psychiatry

DOI

10.1016/0278-5846(94)90125-2

ISSN

0278-5846

Publication Date

October 1994

Volume

18

Issue

6

Start / End Page

995 / 1004

Location

England

Related Subject Headings

  • Sex Characteristics
  • Psychiatry
  • Middle Aged
  • Male
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Creatine
  • Choline
 

Citation

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Charles, H. C., Lazeyras, F., Krishnan, K. R., Boyko, O. B., Patterson, L. J., Doraiswamy, P. M., & McDonald, W. M. (1994). Proton spectroscopy of human brain: effects of age and sex. Prog Neuropsychopharmacol Biol Psychiatry, 18(6), 995–1004. https://doi.org/10.1016/0278-5846(94)90125-2
Charles, H. C., F. Lazeyras, K. R. Krishnan, O. B. Boyko, L. J. Patterson, P. M. Doraiswamy, and W. M. McDonald. “Proton spectroscopy of human brain: effects of age and sex.” Prog Neuropsychopharmacol Biol Psychiatry 18, no. 6 (October 1994): 995–1004. https://doi.org/10.1016/0278-5846(94)90125-2.
Charles HC, Lazeyras F, Krishnan KR, Boyko OB, Patterson LJ, Doraiswamy PM, et al. Proton spectroscopy of human brain: effects of age and sex. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Oct;18(6):995–1004.
Charles, H. C., et al. “Proton spectroscopy of human brain: effects of age and sex.” Prog Neuropsychopharmacol Biol Psychiatry, vol. 18, no. 6, Oct. 1994, pp. 995–1004. Pubmed, doi:10.1016/0278-5846(94)90125-2.
Charles HC, Lazeyras F, Krishnan KR, Boyko OB, Patterson LJ, Doraiswamy PM, McDonald WM. Proton spectroscopy of human brain: effects of age and sex. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Oct;18(6):995–1004.
Journal cover image

Published In

Prog Neuropsychopharmacol Biol Psychiatry

DOI

10.1016/0278-5846(94)90125-2

ISSN

0278-5846

Publication Date

October 1994

Volume

18

Issue

6

Start / End Page

995 / 1004

Location

England

Related Subject Headings

  • Sex Characteristics
  • Psychiatry
  • Middle Aged
  • Male
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Creatine
  • Choline