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A review of 1H MR spectroscopy findings in Alzheimer's disease.

Publication ,  Journal Article
Soher, BJ; Doraiswamy, PM; Charles, HC
Published in: Neuroimaging Clin N Am
November 2005

Hydrogen-1 MR spectroscopy (MRS) studies demonstrate metabolic differences between patients who have Alzheimer's disease (AD) and cognitive normal age-matched controls. Clinical MRS also shows regional variations in metabolites between patients who have AD and those who have other dementias. Single-voxel and volumetric standard MRS techniques and automated data processing software are available for clinical MR scanners. Improvements in specificity and sensitivity of AD diagnosis, using MRS techniques as an adjunct to clinical imaging, are under evaluation. Multiparametric data analyses show, however, that metabolite changes correlate with in-vitro, postmortem, and metabolic changes and to changes in or predictions of cognitive scores.

Duke Scholars

Published In

Neuroimaging Clin N Am

DOI

ISSN

1052-5149

Publication Date

November 2005

Volume

15

Issue

4

Start / End Page

847 / xi

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Spectroscopy
  • Humans
  • Brain
  • Alzheimer Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Soher, B. J., Doraiswamy, P. M., & Charles, H. C. (2005). A review of 1H MR spectroscopy findings in Alzheimer's disease. Neuroimaging Clin N Am, 15(4), 847–xi. https://doi.org/10.1016/j.nic.2005.09.013
Soher, Brian J., P Murali Doraiswamy, and H Cecil Charles. “A review of 1H MR spectroscopy findings in Alzheimer's disease.Neuroimaging Clin N Am 15, no. 4 (November 2005): 847–xi. https://doi.org/10.1016/j.nic.2005.09.013.
Soher BJ, Doraiswamy PM, Charles HC. A review of 1H MR spectroscopy findings in Alzheimer's disease. Neuroimaging Clin N Am. 2005 Nov;15(4):847–xi.
Soher, Brian J., et al. “A review of 1H MR spectroscopy findings in Alzheimer's disease.Neuroimaging Clin N Am, vol. 15, no. 4, Nov. 2005, pp. 847–xi. Pubmed, doi:10.1016/j.nic.2005.09.013.
Soher BJ, Doraiswamy PM, Charles HC. A review of 1H MR spectroscopy findings in Alzheimer's disease. Neuroimaging Clin N Am. 2005 Nov;15(4):847–xi.
Journal cover image

Published In

Neuroimaging Clin N Am

DOI

ISSN

1052-5149

Publication Date

November 2005

Volume

15

Issue

4

Start / End Page

847 / xi

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Spectroscopy
  • Humans
  • Brain
  • Alzheimer Disease