Skip to main content
Journal cover image

Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy.

Publication ,  Journal Article
Kelsey, CR; Mukundan, S; Wang, Z; Hahn, CA; Soher, BJ; Kirkpatrick, JP
Published in: Neuro Oncol
February 2010

The aim of the study was to determine if biochemical changes indicative of injury, assessed using magnetic resonance spectroscopic imaging (SI), are observed after stereotactic radiosurgery (SRS). The study included patients who underwent SI immediately before and 1, 30, and 90 days following SRS. Short TE spectra (TR/TE 1000/35 ms) were acquired at the SRS isocenter with a 2D PRESS-CSI sequence on a single 1.5 T scanner. The SRS isodose lines were overlaid on the magnetic resonance imaging slice utilized for SI data acquisition. N-Acetyl aspartate (NAA)/creatine (Cr) and choline (Cho)/Cr ratios were computed for multiple voxels located between the 25 and 50 cGy isodose lines (low dose) and the 200 and 350 cGy isodose lines (medium dose). An analysis of variance and paired t-tests compared metabolite levels at different time points. Twelve patients were enrolled, although 3 were excluded secondary to poor spectral data quality or deviations from the prescribed SI protocol. The median number of voxels analyzed from the low- and medium-dose region was 7 and 4, respectively. No significant changes in metabolite peak height ratios over time were seen in the low-dose region, for either NAA/Cr (P = .89) or Cho/Cr (P = .85). There was no difference in Cho/Cr peak height ratios in the medium-dose region (P = .62). There was an increase in the NAA/Cr peak height ratio in the medium-dose region between day -1 and day +30 (P = .003), followed by a decline to baseline between days +30 and +90 (P = .03). We did not observe a significant decline in NAA/Cr or change in Cho/Cr peak heights in uninvolved brain parenchyma after SRS.

Duke Scholars

Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

February 2010

Volume

12

Issue

2

Start / End Page

145 / 152

Location

England

Related Subject Headings

  • Radiosurgery
  • Oncology & Carcinogenesis
  • Neurotoxicity Syndromes
  • Magnetic Resonance Spectroscopy
  • Humans
  • Brain Neoplasms
  • Brain
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1109 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kelsey, C. R., Mukundan, S., Wang, Z., Hahn, C. A., Soher, B. J., & Kirkpatrick, J. P. (2010). Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy. Neuro Oncol, 12(2), 145–152. https://doi.org/10.1093/neuonc/nop040
Kelsey, Chris R., Srinivasan Mukundan, Zhiheng Wang, Carol A. Hahn, Brian J. Soher, and John P. Kirkpatrick. “Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy.Neuro Oncol 12, no. 2 (February 2010): 145–52. https://doi.org/10.1093/neuonc/nop040.
Kelsey CR, Mukundan S, Wang Z, Hahn CA, Soher BJ, Kirkpatrick JP. Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy. Neuro Oncol. 2010 Feb;12(2):145–52.
Kelsey, Chris R., et al. “Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy.Neuro Oncol, vol. 12, no. 2, Feb. 2010, pp. 145–52. Pubmed, doi:10.1093/neuonc/nop040.
Kelsey CR, Mukundan S, Wang Z, Hahn CA, Soher BJ, Kirkpatrick JP. Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy. Neuro Oncol. 2010 Feb;12(2):145–152.
Journal cover image

Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

February 2010

Volume

12

Issue

2

Start / End Page

145 / 152

Location

England

Related Subject Headings

  • Radiosurgery
  • Oncology & Carcinogenesis
  • Neurotoxicity Syndromes
  • Magnetic Resonance Spectroscopy
  • Humans
  • Brain Neoplasms
  • Brain
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1109 Neurosciences