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Characterizing stiffness of human prostates using acoustic radiation force.

Publication ,  Journal Article
Zhai, L; Madden, J; Foo, W-C; Mouraviev, V; Polascik, TJ; Palmeri, ML; Nightingale, KR
Published in: Ultrason Imaging
October 2010

Acoustic Radiation Force Impulse (ARFI) imaging has been previously reported to portray normal anatomic structures and pathologies in ex vivo human prostates with good contrast and resolution. These findings were based on comparison with histological slides and McNeal's zonal anatomy. In ARFI images, the central zone (CZ) appears darker (smaller displacement) than other anatomic zones and prostate cancer (PCa) is darker than normal tissue in the peripheral zone (PZ). Since displacement amplitudes in ARFI images are determined by both the underlying tissue stiffness and the amplitude of acoustic radiation force that varies with acoustic attenuation, one question that arises is how the relative displacements in prostate ARFI images are related to the underlying prostatic tissue stiffness. In linear, isotropic elastic materials and in tissues that are relatively uniform in acoustic attenuation (e.g., liver), relative displacement in ARFI images has been shown to be correlated with underlying tissue stiffness. However, the prostate is known to be heterogeneous. Variations in acoustic attenuation of prostatic structures could confound the interpretation of ARFI images due to the associated variations in the applied acoustic radiation force. Therefore, in this study, co-registered three-dimensional (3D) ARFI datasets and quantitative shear wave elasticity imaging (SWEI) datasets were acquired in freshly-excised human prostates to investigate the relationship between displacement amplitudes in ARFI prostate images and the matched reconstructed shear moduli. The lateral time-to-peak (LTTP) algorithm was applied to the SWEI data to compute the shear-wave speed and reconstruct the shear moduli. Five types of prostatic tissue (PZ, CZ, transition zone (TZ) and benign prostatic hyperplasia (BPH), PCa and atrophy) were identified, whose shear moduli were quantified to be 4.1 +/- 0.8 kPa, 9.9 +/- 0.9 kPa, 4.8 +/- 0.6 kPa, 10.0 +/- 1.0 kPa and 8.0 kPa, respectively. Linear regression was performed to compare ARFI displacement amplitudes and the inverse of the corresponding reconstructed shear moduli at multiple depths. The results indicate an inverse relation between ARFI displacement amplitude and reconstructed shear modulus at all depths. These findings support the conclusion that ARFI prostate images portray underlying tissue stiffness variations.

Duke Scholars

Published In

Ultrason Imaging

DOI

ISSN

0161-7346

Publication Date

October 2010

Volume

32

Issue

4

Start / End Page

201 / 213

Location

England

Related Subject Headings

  • Reproducibility of Results
  • Prostatic Neoplasms
  • Prostatic Diseases
  • Prostate
  • Male
  • In Vitro Techniques
  • Imaging, Three-Dimensional
  • Image Processing, Computer-Assisted
  • Humans
  • Elasticity Imaging Techniques
 

Citation

APA
Chicago
ICMJE
MLA
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Zhai, L., Madden, J., Foo, W.-C., Mouraviev, V., Polascik, T. J., Palmeri, M. L., & Nightingale, K. R. (2010). Characterizing stiffness of human prostates using acoustic radiation force. Ultrason Imaging, 32(4), 201–213. https://doi.org/10.1177/016173461003200401
Zhai, Liang, John Madden, Wen-Chi Foo, Vladimir Mouraviev, Thomas J. Polascik, Mark L. Palmeri, and Kathryn R. Nightingale. “Characterizing stiffness of human prostates using acoustic radiation force.Ultrason Imaging 32, no. 4 (October 2010): 201–13. https://doi.org/10.1177/016173461003200401.
Zhai L, Madden J, Foo W-C, Mouraviev V, Polascik TJ, Palmeri ML, et al. Characterizing stiffness of human prostates using acoustic radiation force. Ultrason Imaging. 2010 Oct;32(4):201–13.
Zhai, Liang, et al. “Characterizing stiffness of human prostates using acoustic radiation force.Ultrason Imaging, vol. 32, no. 4, Oct. 2010, pp. 201–13. Pubmed, doi:10.1177/016173461003200401.
Zhai L, Madden J, Foo W-C, Mouraviev V, Polascik TJ, Palmeri ML, Nightingale KR. Characterizing stiffness of human prostates using acoustic radiation force. Ultrason Imaging. 2010 Oct;32(4):201–213.
Journal cover image

Published In

Ultrason Imaging

DOI

ISSN

0161-7346

Publication Date

October 2010

Volume

32

Issue

4

Start / End Page

201 / 213

Location

England

Related Subject Headings

  • Reproducibility of Results
  • Prostatic Neoplasms
  • Prostatic Diseases
  • Prostate
  • Male
  • In Vitro Techniques
  • Imaging, Three-Dimensional
  • Image Processing, Computer-Assisted
  • Humans
  • Elasticity Imaging Techniques