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Dual-mode IVUS transducer for image-guided brain therapy: preliminary experiments.

Publication ,  Journal Article
Herickhoff, CD; Wilson, CM; Grant, GA; Britz, GW; Light, ED; Palmeri, ML; Wolf, PD; Smith, SW
Published in: Ultrasound Med Biol
October 2011

In this study, we investigated the feasibility of using 3.5-Fr intravascular ultrasound (IVUS) catheters for minimally-invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated by: (1) retro-fitting a commercial 3.5-Fr IVUS catheter with a 5 × 0.5 × 0.22 mm PZT-4 transducer for 9-MHz imaging and (2) testing an identical transducer for therapy potential with 3.3-MHz continuous-wave excitation. The imaging transducer was compared with a 9-Fr, 9-MHz ICE catheter when visualizing the post-mortem ovine brain and was also used to attempt vascular access to an in vivo porcine brain. A net average electrical power input of 700 mW was applied to the therapy transducer, producing a temperature rise of +13.5°C at a depth of 1.5 mm in live brain tumor tissue in the mouse model. These results suggest that it may be feasible to combine the imaging and therapeutic capabilities into a single device as a clinically-viable instrument.

Duke Scholars

Published In

Ultrasound Med Biol

DOI

EISSN

1879-291X

Publication Date

October 2011

Volume

37

Issue

10

Start / End Page

1667 / 1676

Location

England

Related Subject Headings

  • Ultrasonography, Interventional
  • Transducers
  • Swine
  • Surgery, Computer-Assisted
  • Sheep, Domestic
  • Phantoms, Imaging
  • Mice, Nude
  • Mice
  • Hyperthermia, Induced
  • Glioblastoma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Herickhoff, C. D., Wilson, C. M., Grant, G. A., Britz, G. W., Light, E. D., Palmeri, M. L., … Smith, S. W. (2011). Dual-mode IVUS transducer for image-guided brain therapy: preliminary experiments. Ultrasound Med Biol, 37(10), 1667–1676. https://doi.org/10.1016/j.ultrasmedbio.2011.06.017
Herickhoff, Carl D., Christy M. Wilson, Gerald A. Grant, Gavin W. Britz, Edward D. Light, Mark L. Palmeri, Patrick D. Wolf, and Stephen W. Smith. “Dual-mode IVUS transducer for image-guided brain therapy: preliminary experiments.Ultrasound Med Biol 37, no. 10 (October 2011): 1667–76. https://doi.org/10.1016/j.ultrasmedbio.2011.06.017.
Herickhoff CD, Wilson CM, Grant GA, Britz GW, Light ED, Palmeri ML, et al. Dual-mode IVUS transducer for image-guided brain therapy: preliminary experiments. Ultrasound Med Biol. 2011 Oct;37(10):1667–76.
Herickhoff, Carl D., et al. “Dual-mode IVUS transducer for image-guided brain therapy: preliminary experiments.Ultrasound Med Biol, vol. 37, no. 10, Oct. 2011, pp. 1667–76. Pubmed, doi:10.1016/j.ultrasmedbio.2011.06.017.
Herickhoff CD, Wilson CM, Grant GA, Britz GW, Light ED, Palmeri ML, Wolf PD, Smith SW. Dual-mode IVUS transducer for image-guided brain therapy: preliminary experiments. Ultrasound Med Biol. 2011 Oct;37(10):1667–1676.
Journal cover image

Published In

Ultrasound Med Biol

DOI

EISSN

1879-291X

Publication Date

October 2011

Volume

37

Issue

10

Start / End Page

1667 / 1676

Location

England

Related Subject Headings

  • Ultrasonography, Interventional
  • Transducers
  • Swine
  • Surgery, Computer-Assisted
  • Sheep, Domestic
  • Phantoms, Imaging
  • Mice, Nude
  • Mice
  • Hyperthermia, Induced
  • Glioblastoma