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Genetically-engineered polypeptide carrier for thermal targeting of therapeutics

Publication ,  Journal Article
Meyer, DE; Kong, G; Dewhirst, M; Chilkoti, A
Published in: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
December 1, 1999

We report the synthesis of a environmentally-responsive polypeptide carrier for thermally-targeted delivery of radionuclide therapeutics. We hypothesized that systemically-injected radionuclide-polypeptide conjugates are likely to be cleared from circulation under physiological conditions, while externally-induced local hyperthermia at tumor sites will result in radionuclide accumulation because of carrier aggregation. We report preliminary in vivo results which support this hypothesis.

Duke Scholars

Published In

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

ISSN

0589-1019

Publication Date

December 1, 1999

Volume

2

Start / End Page

1289
 

Citation

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Meyer, D. E., Kong, G., Dewhirst, M., & Chilkoti, A. (1999). Genetically-engineered polypeptide carrier for thermal targeting of therapeutics. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, 1289.
Meyer, D. E., G. Kong, M. Dewhirst, and A. Chilkoti. “Genetically-engineered polypeptide carrier for thermal targeting of therapeutics.” Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 2 (December 1, 1999): 1289.
Meyer DE, Kong G, Dewhirst M, Chilkoti A. Genetically-engineered polypeptide carrier for thermal targeting of therapeutics. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 1999 Dec 1;2:1289.
Meyer, D. E., et al. “Genetically-engineered polypeptide carrier for thermal targeting of therapeutics.” Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 2, Dec. 1999, p. 1289.
Meyer DE, Kong G, Dewhirst M, Chilkoti A. Genetically-engineered polypeptide carrier for thermal targeting of therapeutics. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 1999 Dec 1;2:1289.

Published In

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

ISSN

0589-1019

Publication Date

December 1, 1999

Volume

2

Start / End Page

1289